{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T21:01:32Z","timestamp":1771707692417,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate if children with neurofibromatosis type 1 (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1) have reduced muscle strength compared with children with typical development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Maximal isometric strength of 15 upper and lower limb muscle groups was evaluated in 30 children with <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 (16 males, 14 females; aged 4\u201316y) and 30 age\u2010, sex\u2010, height\u2010, and weight\u2010matched controls using hand\u2010held dynamometry by a single evaluator. Both the left and right sides were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children with <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 were significantly weaker than children with typical development across all 15 muscle groups assessed (<jats:italic>p<\/jats:italic>&lt;0.05). Apart from elbow flexion, there were no differences between the left and right sides (<jats:italic>p<\/jats:italic>&gt;0.05). Magnitude of differences between the children with <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 compared with the controls ranged from 3% to 43%. Males and females were equally affected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>This study shows that children with <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 have reduced muscle strength compared with children with typical development. This muscle weakness is present from the earliest stages of the disease assessed and persists throughout childhood with no sex difference. These results support recent evidence from mouse studies that <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 is associated with a primary myopathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.12777","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T11:28:59Z","timestamp":1429788539000},"page":"733-736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Muscle weakness in children with neurofibromatosis type 1"],"prefix":"10.1111","volume":"57","author":[{"given":"Kayla M D","family":"Cornett","sequence":"first","affiliation":[{"name":"Institute for Neuroscience and Muscle Research The Children's Hospital at Westmead Sydney NSW Australia"},{"name":"Arthritis and Musculoskeletal Research Group Faculty of Health Sciences The University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn N","family":"North","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Melbourne Vic. Australia"},{"name":"Department of Paediatrics Faculty of Medicine University of Melbourne Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristy J","family":"Rose","sequence":"additional","affiliation":[{"name":"Institute for Neuroscience and Muscle Research The Children's Hospital at Westmead Sydney NSW Australia"},{"name":"Arthritis and Musculoskeletal Research Group Faculty of Health Sciences The University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Burns","sequence":"additional","affiliation":[{"name":"Institute for Neuroscience and Muscle Research The Children's Hospital at Westmead Sydney NSW Australia"},{"name":"Arthritis and Musculoskeletal Research Group Faculty of Health Sciences The University of Sydney Sydney NSW Australia"},{"name":"Murdoch Children's Research Institute Melbourne Vic. 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