{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:38:20Z","timestamp":1761975500378},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T00:00:00Z","timestamp":1434672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Rash, a hypersensitivity reaction, is a common cause of withdrawal from an effective antiepileptic drug (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>) in patients with epilepsy. We present a case of successful desensitization to valproic acid in a 12\u2010year\u2010old male with childhood absence epilepsy and a hypersensitivity reaction, whose epilepsy did not respond to other <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s. Desensitization is a practical therapeutic solution for patients who develop a non\u2010life\u2010threatening hypersensitivity reaction to an <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> for which there may be no substitute.<\/jats:p>","DOI":"10.1111\/dmcn.12835","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T08:11:51Z","timestamp":1434701511000},"page":"1076-1078","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Valproic acid hypersensitivity and desensitization"],"prefix":"10.1111","volume":"57","author":[{"given":"Ori","family":"Toker","sequence":"first","affiliation":[{"name":"Allergy and Clinical Immunology Service Shaare Zedek Medical Center Pediatric Division, Affiliated with Hadassah\u2010Hebrew University Medical School Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuval","family":"Tal","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Unit Department of Medicine Hadassah Medical Center The Hebrew University Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liran","family":"Horev","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hadassah Medical Center The Hebrew University Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorit","family":"Shmoeli","sequence":"additional","affiliation":[{"name":"Jerusalem District Child Development Center Clalit Health Services Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Gilboa","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit Pediatric Division Shaare Zedek Medical Center, Affiliated with Hadassah\u2010Hebrew University Medical School Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2014.04.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000261917.83337.db"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03827.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000156354.20227.F0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000334295.50403.4c"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2013.06.012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12028"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.10.009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871528111312010004"},{"key":"e_1_2_7_11_1","first-page":"158","article-title":"Successful induction of tolerance in an epilepsy patient with phenobarbital allergy","volume":"69","author":"Fr\u00f6scher W","year":"1998","journal-title":"Nervenarzt"},{"key":"e_1_2_7_12_1","first-page":"225","article-title":"Pentobarbital desensitization in a 3\u2010month\u2010old child","volume":"25","author":"Butte MJ","year":"2004","journal-title":"Allergy Asthma Proc"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2014.03.021"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2005.00381.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/323353"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12161"}],"container-title":["Developmental Medicine &amp; 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