{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T16:06:32Z","timestamp":1782403592303,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI13\/00292"],"award-info":[{"award-number":["PI13\/00292"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI11\/00909"],"award-info":[{"award-number":["PI11\/00909"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CP14\/00154"],"award-info":[{"award-number":["CP14\/00154"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CP12\/03121"],"award-info":[{"award-number":["CP12\/03121"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Fetal blood contains higher concentrations of glutamate\u2010oxaloacetate transaminase (<jats:styled-content style=\"fixed-case\">GOT<\/jats:styled-content>; a blood enzyme able to metabolize glutamate) than maternal blood. The aim of this study was to determine the relationship between <jats:styled-content style=\"fixed-case\">GOT<\/jats:styled-content> and glutamate levels in arterial blood samples from umbilical cord in control newborn infants and newborn infants with hypoxic\u2013ischaemic insult and\/or symptoms of hypoxia\u2013ischemia after delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 46 newborn infants (28 females, 18 males) were prospectively included in the study. Twenty\u2010three infants (18 females, five males) were included as control participants and 23 (10 females, 13 males) were included as newborn infants at risk of adverse neurological outcome (defined as umbilical blood with <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> &lt;7.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis of glutamate concentration and <jats:styled-content style=\"fixed-case\">GOT<\/jats:styled-content> activity in umbilical blood samples showed that newborn infants with <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> &lt;7.1 had higher levels of glutamate (142.4\u03bcmol\/L [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 61.4] vs 62.8\u03bcmol\/L [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 25.5]; <jats:italic>p<\/jats:italic>&lt;0.001) and <jats:styled-content style=\"fixed-case\">GOT<\/jats:styled-content> (83.1U\/L [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 60.9] vs 34.9U\/L [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 18.2]; <jats:italic>p<\/jats:italic>&lt;0.001) compared to newborn infants without fetal distress. Analysis of Apgar scores and blood <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> values (markers of perinatal distress) showed that conditions of severe distress were associated with higher glutamate and <jats:styled-content style=\"fixed-case\">GOT<\/jats:styled-content> levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>During fetal development, the ability of <jats:styled-content style=\"fixed-case\">GOT<\/jats:styled-content> to metabolize glutamate suggests that this enzyme can act as an endogenous protective mechanism in the control of glutamate homeostasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.12851","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T07:17:58Z","timestamp":1437722278000},"page":"57-62","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Potential protective role of endogenous glutamate\u2010oxaloacetate transaminase against glutamate excitotoxicity in fetal hypoxic\u2013ischaemic asphyxia"],"prefix":"10.1111","volume":"58","author":[{"given":"Mar\u00eda","family":"P\u00e9rez\u2010Mato","sequence":"first","affiliation":[{"name":"Clinical Neurosciences Research Laboratory Clinical University Hospital Health Research Institute of Santiago de Compostela (IDIS) University of Santiago de Compostela Santiago de Compostela A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Iglesias\u2010Deus","sequence":"additional","affiliation":[{"name":"Neonatology Unit Department of Pediatrics Hospital Clinico Universitario de Santiago Health Research Institute of Santiago de Compostela (IDIS) Santiago de Compostela A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Rujido","sequence":"additional","affiliation":[{"name":"Neonatology Unit Department of Pediatrics Hospital Clinico Universitario de Santiago Health Research Institute of Santiago de Compostela (IDIS) Santiago de Compostela A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"da Silva\u2010Candal","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Research Laboratory Clinical University Hospital Health Research Institute of Santiago de Compostela (IDIS) University of Santiago de Compostela Santiago de Compostela A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1s","family":"Sobrino","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Research Laboratory Clinical University Hospital Health Research Institute of Santiago de Compostela (IDIS) University of Santiago de Compostela Santiago de Compostela A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda\u2010Luz","family":"Couce","sequence":"additional","affiliation":[{"name":"Neonatology Unit Department of Pediatrics Hospital Clinico Universitario de Santiago Health Research Institute of Santiago de Compostela (IDIS) Santiago de Compostela A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Fraga","sequence":"additional","affiliation":[{"name":"Neonatology Unit Department of Pediatrics Hospital Clinico Universitario de Santiago Health Research Institute of Santiago de Compostela (IDIS) Santiago de Compostela A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Castillo","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Research Laboratory Clinical University Hospital Health Research Institute of Santiago de Compostela (IDIS) University of Santiago de Compostela Santiago de Compostela A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Campos","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences Research Laboratory Clinical University Hospital Health Research Institute of Santiago de Compostela (IDIS) University of Santiago de Compostela Santiago de Compostela A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.07.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22670"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61329-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-011-1086-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.1032"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2005.11.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.06.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.04.011"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2007.12.003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2008.09.006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2003.10.018"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.08.011"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2012.05.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000480613","article-title":"Hypoxic\u2010ischemic damage in the neonatal brain: excitatory amino acids","volume":"18","author":"Hagberg H","year":"1992","journal-title":"Dev Pharmacol Ther"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20053"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03335.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1471"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.03.016"},{"key":"e_1_2_7_20_1","first-page":"446","article-title":"Status of liver enzymes in babies with perinatal asphyxia","volume":"20","author":"Islam MT","year":"2011","journal-title":"Mymensingh Med J"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.6106"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.507"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413487444"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2011.11.003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13112104"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2014.11.004"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdmcn.12851","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.12851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:51:37Z","timestamp":1696359097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dmcn.12851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,24]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/dmcn.12851"],"URL":"https:\/\/doi.org\/10.1111\/dmcn.12851","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,24]]},"assertion":[{"value":"2015-06-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}