{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:25:44Z","timestamp":1770974744618,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,26]],"date-time":"2015-07-26T00:00:00Z","timestamp":1437868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess outcome after neonatal perforator stroke in the largest cohort to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Survivors from a cohort of children diagnosed with neonatal perforator stroke using cranial ultrasound or magnetic resonance imaging were eligible for inclusion. Recovery and Recurrence Questionnaire score, presence of cerebral palsy (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>), and crude outcome were assessed, specifically (1) the ability to walk independently, (2) participation in regular education, and (3) the presence of epilepsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven patients (20 males, 17 females) aged 3 to 14\u00a0years (mean age 8y) were included in the study: 14 with isolated single perforator stroke, four with multiple isolated perforator strokes, and 19 with additional brain injury. Out of 18 children with isolated perforator stroke(s), four had<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>, one could not walk independently, and one developed epilepsy. The posterior limb of the internal capsule was involved in four out of 18 patients; three of these patients had<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. Of 19 children with additional brain injury, 11 had<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>and three were not able to walk independently. Three out of nine children with concomitant cortical middle cerebral artery stroke developed epilepsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Perforator stroke patterns can be of use in predicting long\u2010term outcome and for guiding counselling and surveillance. Motor outcome was favourable in children with isolated perforator stroke(s), except when the posterior limb of the internal capsule was involved.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.12857","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T04:59:15Z","timestamp":1437973155000},"page":"49-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Neurodevelopmental outcome after neonatal perforator stroke"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6249-6986","authenticated-orcid":false,"given":"Ginette M","family":"Ecury\u2010Goossen","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Neonatology Erasmus MC\u2010Sophia Children's Hospital Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marit","family":"van der 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