{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:16:00Z","timestamp":1777536960240,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T00:00:00Z","timestamp":1438646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the time trends of neonatal survival and infant neurodevelopmental outcome in very\u2010low\u2010birthweight children at 24\u00a0months corrected age over a 20\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The study cohort comprised 857 infants (439 males and 418 females) weighing less than 1500g at birth or delivered before 32\u00a0weeks gestational age in the period 1989 to 2008. Neurological examination and cognitive assessment of the infants (Bayley Scales of Infant Development and Griffiths Mental Developmental Scale) were performed at 24\u00a0months corrected age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of neonatal survival with normal neurodevelopmental outcome increased from 55.3% (104\/188) in 1989 to 1993, to 61.4% in 1994\u20131998 (116\/189), 68.3% in 1999 to 2003 (138\/202), and 84.5% in 2004 to 2008 (235\/278) (annual increase=1%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.1\u20134.1; <jats:italic>p<\/jats:italic>&lt;0.001). In logistic models, the increase in the rate of normal neurodevelopmental outcome during the periods studied was consistent across the categories of birthweight (\u22641000g as opposed to &gt;1000g), gestational age (\u226428wks as opposed to &gt;28wks), and clinical characteristics (pre\u2010eclampsia\/growth restriction as opposed to spontaneous prematurity\/rupture of membranes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The increased rate of normal neurodevelopmental outcome at 2\u00a0years among very\u2010low\u2010birthweight infants is independent of obstetric risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.12859","type":"journal-article","created":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T07:17:49Z","timestamp":1438672669000},"page":"1035-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Obstetric risk factors and time trends of neurodevelopmental outcome at 2\u00a0years in very\u2010low\u2010birthweight infants: a single institution study"],"prefix":"10.1111","volume":"57","author":[{"given":"Barbara","family":"Gardella","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Fondazione IRCCS Policlinico San Matteo University of Pavia Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Daniela","family":"Iacobone","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Fondazione IRCCS Policlinico San Matteo University of Pavia Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Bogliolo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Fondazione IRCCS Policlinico San Matteo University of Pavia Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Musacchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Fondazione IRCCS Policlinico San Matteo University of Pavia Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Orcesi","sequence":"additional","affiliation":[{"name":"Child Neurology and Psychiatry Unit IRCCS C Mondino National Institute of Neurology Foundation Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chryssoulla","family":"Tzialla","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care Unit Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arsenio","family":"Spinillo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Fondazione IRCCS Policlinico San Matteo University of Pavia Pavia 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