{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:19:57Z","timestamp":1771485597958,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T00:00:00Z","timestamp":1447200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"R\u00e9seau de recherche sur le d\u00e9veloppement"},{"name":"la sant\u00e9 et le bien-\u00eatre de l'enfant des Fonds de Recherche en Sant\u00e9 du Qu\u00e9bec"},{"name":"NeuroDevNet National Centre of Excellence"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We sought to investigate how brain injury and severity, and neurological subtype of cerebral palsy (CP) differed in term\u2010born children with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> after neonatal encephalopathy, between those with suspected birth asphyxia and those without.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Using the Canadian <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> Registry, which included 1001 children, those with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> born at \u226536wks after moderate or severe neonatal encephalopathy, were dichotomized according to the presence or absence of suspected birth asphyxia. Gross Motor Function Classification System (<jats:styled-content style=\"fixed-case\">GMFCS<\/jats:styled-content>) scores, neurological subtypes, comorbidities, and magnetic resonance imaging findings were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 147 term\u2010born children with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> (82 males, 65 females; median age 37 months, interquartile range [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>] 26\u201352.5) who after moderate or severe neonatal encephalopathy had the required outcome data, 61 (41%) met criteria for suspected birth asphyxia. They had a higher frequency of non\u2010ambulatory <jats:styled-content style=\"fixed-case\">GMFCS<\/jats:styled-content> status (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 3.4, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 1.72\u20136.8), spastic quadriplegia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.8, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.4\u20135.6), non\u2010verbal communication skills impairment (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.2, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.0\u20138.6), isolated deep grey matter injury (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.1, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.8\u20139.5), a lower frequency of spastic hemiplegia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.17, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.07\u20130.42), focal injury (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.20; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.04\u20130.93), and more comorbidities (<jats:italic>p<\/jats:italic>=0.017) than those who did not meet criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Term\u2010born children who develop <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> after neonatal encephalopathy with suspected birth asphyxia have a greater burden of disability than those without suspected birth asphyxia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.12953","type":"journal-article","created":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T11:18:49Z","timestamp":1447240729000},"page":"189-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cerebral palsy after neonatal encephalopathy: do neonates with suspected asphyxia have worse outcomes?"],"prefix":"10.1111","volume":"58","author":[{"given":"Jarred","family":"Garfinkle","sequence":"first","affiliation":[{"name":"Department of Pediatrics Montreal Children's Hospital\u2010McGill University Health Center Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Wintermark","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Montreal Children's Hospital\u2010McGill University Health Center Montreal QC Canada"},{"name":"Division of Neonatology Montreal Children's Hospital\u2010McGill University Health Center Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael I","family":"Shevell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Montreal Children's Hospital\u2010McGill University Health Center Montreal QC Canada"},{"name":"Department of Neurology\/Neurosurgery Montreal Children's Hospital\u2010McGill University Health Center Montreal QC Canada"},{"name":"Division of Pediatric Neurology Montreal Children's Hospital\u2010McGill University Health Center Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Oskoui","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Montreal Children's Hospital\u2010McGill University Health Center Montreal QC Canada"},{"name":"Department of Neurology\/Neurosurgery Montreal Children's Hospital\u2010McGill University Health Center Montreal QC Canada"},{"name":"Division of Pediatric Neurology Montreal 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