{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:36:52Z","timestamp":1788910612026,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T00:00:00Z","timestamp":1452729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["353514"],"award-info":[{"award-number":["353514"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Aim<\/jats:title>Pregnancy\u2010induced hypertension\/pre\u2010eclampsia (PIH<\/jats:styled-content>\/PE<\/jats:styled-content>) is associated with cerebral palsy (CP<\/jats:styled-content>) in term births but if sufficiently severe to necessitate preterm delivery predicts a lower risk of CP<\/jats:styled-content> than observed in gestational peers. We investigated whether this apparent \u2018protection\u2019 was attributable to inappropriately chosen comparison groups and\/or an increased risk of perinatal death.<\/jats:p><\/jats:sec>Method<\/jats:title>Perinatal information was collected from medical records of children with CP<\/jats:styled-content>, individually matched neonatal survivors without CP<\/jats:styled-content>, and representative samples of perinatal deaths of Western Australian birth cohorts from 1980 to 1995. Compared with these data, the sensitivity of statutorily collected PIH<\/jats:styled-content>\/PE<\/jats:styled-content> data was assessed for each outcome group. Using these sensitivities, the estimated risks of death and CP<\/jats:styled-content> in births to all women with and without PIH<\/jats:styled-content>\/PE<\/jats:styled-content> were compared.<\/jats:p><\/jats:sec>Results<\/jats:title>Sensitivity of statutory PIH<\/jats:styled-content>\/PE<\/jats:styled-content> data decreased with increasingly poor outcome. Reconstructed cohorts showed that PIH<\/jats:styled-content>\/PE<\/jats:styled-content> increased the risks both of CP<\/jats:styled-content> and of perinatal death in births at lower gestations except in births <27\u00a0weeks, where the risk of perinatal death only increased greatly.<\/jats:p><\/jats:sec>Interpretation<\/jats:title>PIH<\/jats:styled-content>\/PE<\/jats:styled-content> does not protect against poor outcome at any gestational age. Previously reported protective effects originate from inappropriate control for gestational age and not from higher gestation\u2010specific perinatal mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13014","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T17:31:42Z","timestamp":1452792702000},"page":"76-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cerebral palsy and perinatal mortality after pregnancy\u2010induced hypertension across the gestational age spectrum: observations of a reconstructed total population cohort"],"prefix":"10.1111","volume":"58","author":[{"given":"Eve","family":"Blair","sequence":"first","affiliation":[{"name":"Telethon Kids Institute University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Watson","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia Perth WA Australia"},{"name":"Department of Health Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Australian Cerebral Palsy Register Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,14]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"333","volume-title":"Turnbull's Obstetrics","author":"Greer I","year":"2001"},{"key":"e_1_2_7_3_1","volume-title":"Report of the Western Australian Cerebral Palsy Register to Birth Year 1999","author":"Watson L","year":"2006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1985.02140120077032"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1542\/peds.97.5.780a","article-title":"Cerebral palsy in very low birth weight infants, pre\u2010eclampsia and magnesium sulfate","volume":"97","author":"Blair E","year":"1996","journal-title":"Pediatrics"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009458"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2004.02.011"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.11.1417"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.20.2677"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.1998.00134.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.05.011"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj275"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp024"},{"key":"e_1_2_7_14_1","volume-title":"Validation Study of the Wester Australian Midwives' Notification System 1986","author":"Hill C","year":"1987"},{"key":"e_1_2_7_15_1","volume-title":"Validation Study of the Western Australian Midwives' Notification System 1992","author":"Gee V","year":"1994"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2010.01157.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f4089"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.10.1103"}],"container-title":["Developmental Medicine & Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdmcn.13014","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.13014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T09:12:43Z","timestamp":1694682763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dmcn.13014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,14]]},"references-count":17,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/dmcn.13014"],"URL":"https:\/\/doi.org\/10.1111\/dmcn.13014","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,14]]},"assertion":[{"value":"2015-06-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}