{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:18:21Z","timestamp":1789827501011,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T00:00:00Z","timestamp":1461196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Mucopolysaccharidoses (<jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>) are a group of diseases with an almost 100% lifetime incidence of carpal tunnel syndrome (<jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>subtypes I, <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content>. We compared nerve ultrasound with clinical signs and electrophysiology in a clinical setting to screen for <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content>in <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Twenty\u2010four patients (13 male, 11 female, mean age of 7y 11mo [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>8y 5mo], range 6mo\u201329y) were screened for <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content>. Eight of these patients were re\u2010examined post\u2010operatively. Clinical signs, distal motor latency, compound muscle action potential, sensory nerve action potential amplitude and velocity, as well as echogenicity and the cross\u2010sectional area (<jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>) of the median nerve at the wrist and forearm determined with ultrasound were assessed and the wrist to forearm ratio (<jats:styled-content style=\"fixed-case\">WFR<\/jats:styled-content>) calculated. Eighteen healthy participants formed a comparison group, who were also investigated with nerve ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 26% of the patients' hands, clinical signs of <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content>were present; 77% fulfilled electrophysiological and 92% nerve ultrasound criteria for <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content>. Post\u2010operatively, electrophysiology improved significantly, whereas ultrasound results were unchanged. In the comparison group, age and height correlated with the <jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>, but not with <jats:styled-content style=\"fixed-case\">WFR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Nerve ultrasound is a useful and painless primary screening tool for <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content>in <jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13127","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T13:19:57Z","timestamp":1461244797000},"page":"1172-1179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Nerve ultrasound in clinical management of carpal tunnel syndrome in mucopolysaccharidosis"],"prefix":"10.1111","volume":"58","author":[{"given":"Tobias","family":"B\u00e4umer","sequence":"first","affiliation":[{"name":"Department of Paediatric and Adult Movement Disorders and Neuropsychiatry Institute of Neurogenetics University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"Department of Neurology University Medical Hospital Hamburg\u2013Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"B\u00fchring","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Medical Hospital Hamburg\u2013Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schelle","sequence":"additional","affiliation":[{"name":"Department of Neurology St\u00e4dtisches Klinikum Dessau Dessau Rosslau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"M\u00fcnchau","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Adult Movement Disorders and Neuropsychiatry Institute of Neurogenetics University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Muschol","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Medical Hospital Hamburg\u2013Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,21]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"79","article-title":"Carpal tunnel syndrome in children with mucopolysaccharidoses: needs for surgical tendons and median nerve release","volume":"32","author":"Pronicka E","year":"1988","journal-title":"J Ment Defic Res"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807300528"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21431"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.79B4.7547"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2012.02.026"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.115337"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.01.101"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307389300800408"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-011-0632-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-012-9572-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1637-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2501080397"},{"issue":"12","key":"e_1_2_7_16_1","first-page":"S21","article-title":"Evaluating the mean cross\u2010sectional area (CSA) of median nerve by use of ultrasound in Thai population","volume":"95","author":"Wanitwattanarumlug B","year":"2012","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.03.007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23718"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23912"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0184-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000169017.79374.93"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0163-y"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22264"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20982"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000143799.88513.47"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009741003685632"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdmcn.13127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdmcn.13127","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.13127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:05:59Z","timestamp":1696349159000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dmcn.13127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,21]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/dmcn.13127"],"URL":"https:\/\/doi.org\/10.1111\/dmcn.13127","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,21]]},"assertion":[{"value":"2016-02-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}