{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:38:46Z","timestamp":1777642726751,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T00:00:00Z","timestamp":1463961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the possible association between major neonatal morbidities and poor head growth from birth to discharge home in very\u2010low\u2010birthweight (VLBW) infants born preterm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Population\u2010based observational study comprising 12 992 infants (6340 male, 6652 female) of 24 to 32 weeks' gestation, and birthweight \u22641500g. Severe head growth failure (<jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content>) was defined as a decrease in head circumference z\u2010score &gt;2 z\u2010scores, and moderate <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> as a decrease of 1 to 2 z\u2010scores. Multinomial logistic regression analysis was applied to determine morbidities associated with <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Severe <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> occurred in 4.5% and moderate <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> in 20.9% of infants. Each unit increase in head circumference z\u2010score at birth was associated with increased odds for severe and moderate <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> (odds ratios [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 5.29, 95% confidence intervals [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 4.67\u20136.00, and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.38, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.23\u20132.54 respectively). Both severe and moderate <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> were associated with respiratory distress syndrome (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.03, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.58\u20132.62, and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.66, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.48\u20131.85 respectively); bronchopulmonary dysplasia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.38, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.33\u20134.91, and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.87, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.52\u20132.30 respectively); necrotizing enterocolitis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.89, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.04\u20134.09, and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.72, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.38\u20132.16 respectively), and sepsis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.06, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.69\u20132.50, and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.38, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.24\u20131.53 respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Major neonatal morbidities were associated with <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> in VLBW infants born preterm. Identification of whether this is a direct effect of these morbidities or mediated through nutritional or growth factors may enable interventions to improve postnatal head growth of infants born preterm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13153","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T14:12:35Z","timestamp":1464099155000},"page":"1159-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Association between neonatal morbidities and head growth from birth until discharge in very\u2010low\u2010birthweight infants born preterm: a population\u2010based study"],"prefix":"10.1111","volume":"58","author":[{"given":"Rivka H","family":"Regev","sequence":"first","affiliation":[{"name":"Department of Neonatology Meir Hospital Sapir Medical Center Kfar Saba Israel"},{"name":"Sackler Medical School Tel Aviv University Tel Aviv 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