{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T11:15:34Z","timestamp":1759058134230,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T00:00:00Z","timestamp":1463961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIDCD R24 DC008646\u201002"],"award-info":[{"award-number":["NIDCD R24 DC008646\u201002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR 000424\u201006"],"award-info":[{"award-number":["UL1 TR 000424\u201006"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>This cross\u2010sectional investigation aimed to assess the value of non\u2010invasive measures of temporal respiratory\u2013swallow coupling in individuals with ataxic swallowing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Twenty participants (11 males, 9 females; range 9\u201021y) with ataxia telangiectasia were presented with water and pudding boluses. Their 193 swallows were compared with 2200 swallows from 82 age\u2010matched healthy controls. The two components of airway protection during swallowing that were analyzed were: direction of peri\u2010deglutitive airflow and duration of deglutitive inhibition of respiratory airflow (<jats:styled-content style=\"fixed-case\">DIORA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Safe expiratory patterns of peri\u2010deglutitive airflow occurred significantly less often in participants with ataxia telangiectasia than in age\u2010matched control participants (younger <jats:italic>p<\/jats:italic>&lt;0.015 and older <jats:italic>p<\/jats:italic>&lt;0.001). The frequency of an expiratory pattern of peri\u2010deglutitive airflow increased with age in participants in the comparison group (<jats:italic>p<\/jats:italic>=0.006), but not in those with ataxia telangiectasia (<jats:italic>p<\/jats:italic>=0.234). With age, mean duration of <jats:styled-content style=\"fixed-case\">DIORA<\/jats:styled-content> decreased in controls (<jats:italic>p<\/jats:italic>&lt;0.001) but was unchanged in participants with ataxia telangiectasia (<jats:italic>p<\/jats:italic>=0.164).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Non\u2010invasive quantitative measures of respiratory\u2013swallow coupling capture temporal relationships that plausibly contribute to airway compromise from dysphagia. Changes in respiratory\u2013swallow coupling observed with advancing age in control participants were not seen in participants with ataxia telangiectasia. Measures of perturbations may herald swallowing problems prior to development of pulmonary and nutritional sequelae.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13156","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T10:14:22Z","timestamp":1464084862000},"page":"1069-1075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Assessment of impaired coordination between respiration and deglutition in children and young adults with ataxia telangiectasia"],"prefix":"10.1111","volume":"58","author":[{"given":"Maureen A","family":"Lefton\u2010Greif","sequence":"first","affiliation":[{"name":"Department of Pediatrics Johns Hopkins Medical Institutions Baltimore MD USA"},{"name":"The Eudowood Division of Pediatric Respiratory Sciences Johns Hopkins Medical Institutions Baltimore MD USA"},{"name":"The Ataxia\u2010Telangiectasia Clinical Center Johns Hopkins Medical Institutions Baltimore MD 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