{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:42:47Z","timestamp":1769042567043,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the antiepileptic effect of hypothermia and its association with neurological outcome in infants with moderate and severe hypoxic\u2013ischemic encephalopathy (<jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We compared polygraphic electroencephalography monitoring and outcome data in 39 cooled and 33 non\u2010cooled term newborn infants, born between January 2005 and March 2013, and hospitalized because of signs of asphyxia and moderate to severe <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cooled newborn infants had fewer seizures (14\/39 vs 20\/33 <jats:italic>p<\/jats:italic>=0.036) and status epilepticus (7\/39 vs 13\/33, <jats:italic>p<\/jats:italic>=0.043), a lower mean duration of seizures (18mins vs 133mins, <jats:italic>p<\/jats:italic>=0.026), fewer administered antiepileptic drugs (median 0 vs 1, <jats:italic>p<\/jats:italic>=0.045), and more commonly a good outcome at 24 months (normal\/mild motor impairment in 32\/39 vs 16\/33, <jats:italic>p<\/jats:italic>=0.003). Seizure burden (accumulated duration of seizures over a defined period) in cooled patients with both moderate (0.0 vs 0.1; <jats:italic>p<\/jats:italic>=0.045) and severe <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content> (0.3 vs 4.9; <jats:italic>p<\/jats:italic>=0.018) was lower than in non\u2010cooled patients. Compared with non\u2010cooled patients, a good outcome was more common in cooled newborn infants with severe <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content> (<jats:italic>p<\/jats:italic>=0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Hypothermia has an antiepileptic effect in both moderate and severe neonatal <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content>. The lower seizure burden in cooled newborn infants with severe <jats:styled-content style=\"fixed-case\">HIE<\/jats:styled-content> is more commonly associated with normal outcome at 24 months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13195","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T10:32:41Z","timestamp":1469183561000},"page":"1235-1241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Hypothermia reduces seizure burden and improves neurological outcome in severe hypoxic\u2013ischemic encephalopathy: an observational study"],"prefix":"10.1111","volume":"58","author":[{"given":"Isotta","family":"Guidotti","sequence":"first","affiliation":[{"name":"Division of Neonatal Intensive Care Unit Department of Pediatrics University Hospital Modena 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