{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:32:13Z","timestamp":1790040733358,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,7,16]],"date-time":"2016-07-16T00:00:00Z","timestamp":1468627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004365","name":"Sydney Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The long\u2010term outcomes of childhood infective encephalitis are variable and not well quantified. We aimed to systematically review the literature and undertake meta\u2010analyses on predetermined outcomes to address this knowledge gap and identify areas for future research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We searched electronic databases, performed complementary reviews of references of fully extracted articles, and made contact with experts on infective encephalitis. Articles published up until April 2016 were selected for screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We evaluated sequelae of 1018 survivors of childhood infective encephalitis (934 with complete follow\u2010up) from 16 studies. Mean age during acute encephalitis episodes was 5 years 3.6 months (range 1.2mo\u201317y), 57.6% were male (500\/868), and mean follow\u2010up period was 4 years 1.2 months (range 1\u201312y). Incomplete recovery was reported in 312 children (42.0%; 95% confidence interval [\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ] 31.6\u201353.1% in pooled estimate). Among the other sequelae, developmental delay, abnormal behaviour, motor impairment, and seizures were reported among 35.0% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      10.0\u201365.0%), 18.0% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      8.0\u201331.0%), 17.0% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      10.0\u201326.0%), and 10.0% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      6.0\u201314.0%) respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Almost half of childhood infective encephalitis survivors report incomplete recovery in the long\u2010term; most commonly developmental delay, behavioural abnormality, and neurological impairments (i.e. seizure). Well designed, large\u2010scale prospective studies are needed to better quantify neurodevelopmental sequelae among childhood encephalitis survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.13197","type":"journal-article","created":{"date-parts":[[2016,7,16]],"date-time":"2016-07-16T03:22:40Z","timestamp":1468639360000},"page":"1108-1115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Long\u2010term outcomes of infective encephalitis in children: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"58","author":[{"given":"Gulam","family":"Khandaker","sequence":"first","affiliation":[{"name":"Discipline of Child and Adolescent Health Sydney Medical School University of Sydney Sydney NSW Australia"},{"name":"National Centre for Immunisation Research and Surveillance The Children's Hospital at Westmead Sydney NSW Australia"},{"name":"Marie Bashir Institute for Infectious Diseases and Biosecurity Institute (MBI) University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Jung","sequence":"additional","affiliation":[{"name":"Discipline of Child and Adolescent Health Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N","family":"Britton","sequence":"additional","affiliation":[{"name":"Discipline of Child and Adolescent Health Sydney Medical School University of Sydney Sydney NSW Australia"},{"name":"Marie Bashir Institute for Infectious Diseases and Biosecurity Institute (MBI) University of Sydney Sydney NSW Australia"},{"name":"Department of Infectious Diseases and Microbiology The Children's Hospital at Westmead Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"King","sequence":"additional","affiliation":[{"name":"National Centre for Immunisation Research and Surveillance The Children's Hospital at Westmead Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Kevin","family":"Yin","sequence":"additional","affiliation":[{"name":"National Centre for Immunisation Research and Surveillance The Children's Hospital at Westmead Sydney NSW Australia"},{"name":"Sydney School of Public Health University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl A","family":"Jones","sequence":"additional","affiliation":[{"name":"Discipline of Child and Adolescent Health Sydney Medical School University of Sydney Sydney NSW Australia"},{"name":"Marie Bashir Institute for Infectious Diseases and Biosecurity Institute (MBI) University of Sydney Sydney NSW Australia"},{"name":"Department of Infectious Diseases and Microbiology The Children's Hospital at Westmead Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103496"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32832b4c47"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162206000636"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290508"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871526514666141021113317"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000086"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308468"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300100"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073812469443"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trt064"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065954"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307372"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.4580"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit922"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03651.x"},{"key":"e_1_2_8_17_1","first-page":"334","article-title":"Cost\u2010effectiveness of routine immunization to control Japanese encephalitis in Shanghai, China","volume":"81","author":"Ding D","year":"2003","journal-title":"Bull World Health Organ"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002533"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-5-134"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0902.020218"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1509.081540"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja14.01042"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12749"},{"key":"e_1_2_8_24_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]","author":"Higgins JPT","year":"2011"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00455.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-2848"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2702"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.77.528"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0148"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1991.tb14794.x"},{"key":"e_1_2_8_32_1","first-page":"1143","article-title":"Clinical outcome and neurological sequelae in serologically confirmed cases of Japanese encephalitis patients in Assam, India","volume":"39","author":"Baruah HC","year":"2002","journal-title":"Indian Pediatr"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.80.1.69"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3010"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31824f23c0"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-3188"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.01.037"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/7010.2006.00223"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1547"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2006.09.010"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.204677"},{"key":"e_1_2_8_42_1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/INF.0b013e318290614f","article-title":"Epidemiology, outcomes and predictors of recovery in childhood encephalitis: a hospital\u2010based study","volume":"32","author":"DuBray K","year":"2013","journal-title":"Pediatr Infect Dis J"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268810000725"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117326"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199708213370810"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d549"}],"updated-by":[{"DOI":"10.1111\/dmcn.13358","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T00:00:00Z","timestamp":1481155200000}}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdmcn.13197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdmcn.13197","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.13197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:06:52Z","timestamp":1696334812000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dmcn.13197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,16]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/dmcn.13197"],"URL":"https:\/\/doi.org\/10.1111\/dmcn.13197","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,16]]},"assertion":[{"value":"2016-05-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}