{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:08:03Z","timestamp":1777788483050,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T00:00:00Z","timestamp":1473984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the contribution of somatosensory evoked potentials after median nerve (<jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content>s) and posterior tibial nerve (<jats:styled-content style=\"fixed-case\">PTN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content>s) stimulation in functional assessment of cervical and lumbar spinal stenosis in children with achondroplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We reviewed <jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content>s, <jats:styled-content style=\"fixed-case\">PTN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content>s, and spinal magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) examinations performed in 58 patients with achondroplasia (25 males, 33 females; age range 21d\u201316y 10mo; mean age 4y 3mo [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 4y 1mo]). Patients were subdivided into four age categories: &lt;2 years, between 2 to 4 years, between 4 to 8 years, and \u22658 years. The peak latency of P37 for <jats:styled-content style=\"fixed-case\">PTN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content>s, the peak latencies of N11, N13, P14, and N20, and the N13\u2013N20 interpeak latency (<jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>) for <jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content>s were collected; the diagnostic accuracy measures of these parameters (analysis of receiver operating characteristic [<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>] curves) with respect to the presence of foramen magnum or lumbar spinal stenosis were analysed in each age category.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve analysis showed that the most sensitive parameter in detecting the presence of foramen magnum stenosis was P37 latency in the first two age categories (&lt;2y and \u22652\u20134y; sensitivity 0.63, specificity 1.00, and sensitivity 1.00, specificity 0.75 respectively). In the third age category (\u22654\u20138y), the most sensitive parameter in detecting the presence of foramen magnum stenosis was <jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>s N13\u2013N20 (sensitivity 0.73, specificity 0.87), whereas in the last age category (\u22658y), the most important parameter was N20 latency (sensitivity 0.75, specificity 0.77).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>In children with achondroplasia, the cortical component of <jats:styled-content style=\"fixed-case\">PTN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content>s is more sensitive than the cortical component and central conduction time of <jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SEP<\/jats:styled-content>s in detection of cervical spinal cord compression at early ages.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13243","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T11:49:24Z","timestamp":1474026564000},"page":"192-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Early impairment of somatosensory evoked potentials in very young children with achondroplasia with foramen magnum stenosis"],"prefix":"10.1111","volume":"59","author":[{"given":"Stefania","family":"Fornarino","sequence":"first","affiliation":[{"name":"Head\u2010Neck and Neuroscience Department Child Neuropsychiatry Unit Istituto Giannina Gaslini Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Paola","family":"Rossi","sequence":"additional","affiliation":[{"name":"Head\u2010Neck and Neuroscience Department Child Neuropsychiatry Unit Istituto Giannina Gaslini Genova 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