{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:49:55Z","timestamp":1782776995629,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T00:00:00Z","timestamp":1474588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Yale University Burr Chamberlin Memorial Fellowship"},{"name":"Dancing Eye Syndrome Support Trust"},{"DOI":"10.13039\/100012107","name":"The Waterloo Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012107","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Opsoclonus\u2013myoclonus syndrome (<jats:styled-content style=\"fixed-case\">OMS<\/jats:styled-content>) is a rare, poorly understood condition that can result in long\u2010term cognitive, behavioural, and motor sequelae. Several studies have investigated structural brain changes associated with this condition, but little is known about changes in function. This study aimed to investigate changes in brain functional connectivity in patients with <jats:styled-content style=\"fixed-case\">OMS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Seven patients with <jats:styled-content style=\"fixed-case\">OMS<\/jats:styled-content> and 10 age\u2010matched comparison participants underwent 3T magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) to acquire resting\u2010state functional <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> data (whole\u2010brain echo\u2010planar images; 2mm isotropic voxels; multiband factor \u00d72) for a cross\u2010sectional study. A seed\u2010based analysis identified brain regions in which signal changes over time correlated with the cerebellum. Model\u2010free analysis was used to determine brain networks showing altered connectivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with <jats:styled-content style=\"fixed-case\">OMS<\/jats:styled-content>, the motor cortex showed significantly reduced connectivity, and the occipito\u2010parietal region significantly increased connectivity with the cerebellum relative to the comparison group. A model\u2010free analysis also showed extensive connectivity within a visual network, including the cerebellum and basal ganglia, not present in the comparison group. No other networks showed any differences between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">OMS<\/jats:styled-content> showed reduced connectivity between the cerebellum and motor cortex, but increased connectivity with occipito\u2010parietal regions. This pattern of change supports widespread brain involvement in <jats:styled-content style=\"fixed-case\">OMS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13262","type":"journal-article","created":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T10:54:00Z","timestamp":1474628040000},"page":"98-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Altered functional brain connectivity in children and young people with opsoclonus\u2013myoclonus syndrome"],"prefix":"10.1111","volume":"59","author":[{"given":"Adam M","family":"Chekroud","sequence":"first","affiliation":[{"name":"FMRIB Centre Nuffield Department of Clinical Neurosciences John Radcliffe Hospital University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Anand","sequence":"additional","affiliation":[{"name":"Oxford Children's Hospital John Radcliffe Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Yong","sequence":"additional","affiliation":[{"name":"Oxford Children's Hospital John Radcliffe Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pike","sequence":"additional","affiliation":[{"name":"Oxford Children's Hospital John Radcliffe Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Bridge","sequence":"additional","affiliation":[{"name":"FMRIB Centre Nuffield Department of Clinical Neurosciences John Radcliffe Hospital University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2009.03.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454204272560"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52910-7.00042-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32833fde3f"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12594"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.01.051"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.07.055"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.045"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.09.016"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2003.822821"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn059"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811879106"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws067"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00344353"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0101"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361302006004009"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.1.86"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.12.030189.002113"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01290.2004"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2009.08.005"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200402000-00005"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-152823"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-006-0247-4"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.01.022"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073816634856"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5569-09.2010"}],"container-title":["Developmental Medicine &amp; 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