{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:40:06Z","timestamp":1789044006594,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,8]],"date-time":"2016-10-08T00:00:00Z","timestamp":1475884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03HD61084"],"award-info":[{"award-number":["R03HD61084"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Jaundice may cause auditory toxicity (auditory neuropathy and hearing loss). However, total serum bilirubin (<jats:styled-content style=\"fixed-case\">TSB<\/jats:styled-content>) does not discriminate neonates at risk for auditory toxicity. We compared <jats:styled-content style=\"fixed-case\">TSB<\/jats:styled-content>, bilirubin:albumin molar ratio (<jats:styled-content style=\"fixed-case\">BAMR<\/jats:styled-content>), and unbound bilirubin for their association with auditory toxicity in neonates with severe jaundice (<jats:styled-content style=\"fixed-case\">TSB<\/jats:styled-content> \u2265342\u03bcmol\/L, or that met exchange transfusion).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Neonates greater or equal to 34 weeks gestational age with severe jaundice during the first 2 postnatal weeks were eligible for prospective cohort study, unless they had craniofacial malformations, chromosomal disorders, toxoplasmosis, other infections, rubella, cytomegalovirus, herpes simplex infections, surgery, or family history of congenital deafness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight out of 100 neonates (mean gestational age 37.4wks; 59 males, 41 females) had auditory toxicity. Peak unbound bilirubin, but not peak <jats:styled-content style=\"fixed-case\">TSB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BAMR<\/jats:styled-content>, was associated with auditory toxicity (<jats:italic>p<\/jats:italic>&lt;0.05) in neonates with severe (<jats:styled-content style=\"fixed-case\">TSB<\/jats:styled-content> &lt;427.5\u03bcmol\/L) and extreme hyperbilirubinemia (<jats:styled-content style=\"fixed-case\">TSB<\/jats:styled-content> \u2265427.5\u03bcmol\/L). Area under the receiver operating characteristic curve for unbound bilirubin (0.78) was significantly greater (<jats:italic>p<\/jats:italic>=0.03) than <jats:styled-content style=\"fixed-case\">TSB<\/jats:styled-content> (0.54) among neonates with severe but not extreme hyperbilirubinemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Unbound bilirubin is more strongly associated with auditory toxicity than <jats:styled-content style=\"fixed-case\">TSB<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">BAMR<\/jats:styled-content> in greater or equal to 34 weeks gestational age neonates with severe jaundice. Unbound bilirubin is a better predictor than <jats:styled-content style=\"fixed-case\">TSB<\/jats:styled-content> in neonates with severe hyperbilirubinemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13284","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T06:35:52Z","timestamp":1476340552000},"page":"297-303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Auditory toxicity in late preterm and term neonates with severe jaundice"],"prefix":"10.1111","volume":"59","author":[{"given":"Sanjiv B","family":"Amin","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Saluja","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sir Ganga Ram Hospital Delhi 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