{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:03:58Z","timestamp":1783400638068,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swiss Neuropediatric Stroke group"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Paediatric arterial ischaemic stroke can lead to reduced quality of life (QoL). It is important to identify predictors of QoL to support recovery. We examined long\u2010term QoL after arterial ischaemic stroke concerning different variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Children registered in the Swiss Neuropediatric Stroke Registry and suffering from arterial ischaemic stroke between 2000 and 2008 were included. Two years post\u2010stroke, assessments included intelligence quotient tests for cognitive impairment and modified Rankin Scale (<jats:styled-content style=\"fixed-case\">mRS<\/jats:styled-content>) for neurological impairment; 5 years post\u2010stroke, the Kidscreen\u201027 was used for QoL, DSM\u2010IV criteria screening was used for attention deficits, and the <jats:styled-content style=\"fixed-case\">ABILHAND<\/jats:styled-content>\u2010Kids was used for manual motor skills. Age at stroke, sex, socioeconomic status, lesion characteristics, neuropsychological and motor outcome, and <jats:styled-content style=\"fixed-case\">mRS<\/jats:styled-content> were correlated with QoL measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy children were examined (49 males, 21 females; mean age 7y 2wks). Age at stroke, sex, socioeconomic status, and lesion characteristics did not influence QoL; <jats:styled-content style=\"fixed-case\">IQ<\/jats:styled-content> below average and attention deficits partially influenced QoL. The highest predictive value for QoL was found for manual motor impairment (<jats:italic>p<\/jats:italic>=0.002) and <jats:styled-content style=\"fixed-case\">mRS<\/jats:styled-content> scores (<jats:italic>p<\/jats:italic>=0.013). Combined motor, cognitive, and attention impairment negatively affected QoL (<jats:italic>p<\/jats:italic>=0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Neurological and cognitive impairments after paediatric arterial ischaemic stroke negatively influence QoL. Children with motor and neurological problems, as well as those with combined motor, cognitive, and attention problems, are at higher risk for low QoL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13295","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T11:03:10Z","timestamp":1477047790000},"page":"45-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Quality of life after paediatric ischaemic stroke"],"prefix":"10.1111","volume":"59","author":[{"given":"Salome","family":"Kornfeld","sequence":"first","affiliation":[{"name":"University Children's Hospital Bern Bern Switzerland"},{"name":"Center for Cognition, Learning and Memory University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Studer","sequence":"additional","affiliation":[{"name":"University Children's Hospital Bern Bern Switzerland"},{"name":"Center for Cognition, Learning and Memory University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Winkelbeiner","sequence":"additional","affiliation":[{"name":"University Children's Hospital Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ria","family":"Reg\u00e9nyi","sequence":"additional","affiliation":[{"name":"University Children's Hospital Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugen","family":"Boltshauser","sequence":"additional","affiliation":[{"name":"University Children's Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Steinlin","sequence":"additional","affiliation":[{"name":"University Children's Hospital Bern Bern Switzerland"},{"name":"Center for Cognition, Learning and Memory University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Swiss Neuropediatric Stroke group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-837658"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297040701792383"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2009.03403.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2012.661117"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22381"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380201700606"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811408609"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2000.tb00348.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.094607"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ab.20271"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000162"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/35004593"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2005.tb01130.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01321080"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198903001-00008"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000138423.77640.37"},{"key":"e_1_2_8_18_1","unstructured":"CarlyneA.(2007)ABILHAND\u2010Kids: a measure of manual ability for children with upper limb impairment.http:\/\/www.rehab-scales.org\/(accessed 18 August 2015)."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2013.09.015"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(98)00411-0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12222"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2009.03580.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11199-006-9138-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.132.1.98"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15326942dn2701_3"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200402000-00019"}],"container-title":["Developmental Medicine &amp; 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