{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:21:06Z","timestamp":1788970866200,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"David and Beatrice Reidford Research Scholarship"},{"name":"University of Alberta Faculty of Medicine and Dentistry Research Office"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Autistic regression is a unique variant within the autism spectrum disorders (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>s), with recent reports raising the possibility of immune aetiology. This study explores clinical clues for an association between autistic regression and autoimmunity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Single\u2010centre charts of children diagnosed with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> in 2014 were reviewed. We compared the rates of: (1) familial autoimmunity in first\u2010degree and second\u2010degree relatives; (2) febrile illness preceding initial parental concern, as a potential precipitant of immune activation; and (3) possible non\u2010immune precipitants such as pregnancy and postnatal complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The charts of 206 children with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> and 33 diagnosed with autistic regression variant were reviewed. The incidence of febrile illness in the 6\u00a0months prior to initial parental concern was significantly higher in the children with autistic regression compared with those with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> (30% vs 0%; <jats:italic>p<\/jats:italic>&lt;0.001). The overall prevalence of familial autoimmunity was also higher in children with autistic regression compared with those with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> (33% vs 12%; <jats:italic>p<\/jats:italic>&lt;0.001). Type 1 diabetes and autoimmune thyroiditis were both more common in families with children with autistic regression. Other non\u2010immune risk factors did not differ between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our findings suggest that predisposition to autoimmunity, and immune\/inflammatory activation, may be associated with autistic regression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13432","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T12:09:33Z","timestamp":1491480573000},"page":"947-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Clinical clues for autoimmunity and neuroinflammation in patients with autistic regression"],"prefix":"10.1111","volume":"59","author":[{"given":"Ori","family":"Scott","sequence":"first","affiliation":[{"name":"Department of Paediatrics The Hospital for Sick Children Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diya","family":"Shi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Dentistry University of Alberta Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Andriashek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Glenrose Rehabilitation Hospital Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Glenrose Rehabilitation Hospital Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-3741","authenticated-orcid":false,"given":"Helly R","family":"Goez","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology University of Alberta Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0025234"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1998.tb10087.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.2107"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15326942dn2703_2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.4.560"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.28561"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-14-70"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716002038"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073813501875"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13169"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.105355"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03834.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02172145"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.51.6.1173"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.08.003"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.42"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2445"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-005-0071-0"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10557"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.101"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39320"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199508000-00022"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02172828"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/13590840600681827"}],"container-title":["Developmental Medicine &amp; 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