{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:37:27Z","timestamp":1770449847349,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cure AHC","award":["3916290"],"award-info":[{"award-number":["3916290"]}]},{"name":"Duke University funds"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To characterize motor function profiles in alternating hemiplegia of childhood, and to investigate interrelationships between these domains and with age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We studied a cohort of 23 patients (9 males, 14 females; mean age 9y 4mo, range 4mo\u201343y) who underwent standardized tests to assess gross motor, upper extremity motor control, motor speech, and dysphagia functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gross Motor Function Classification System (<jats:styled-content style=\"fixed-case\">GMFCS<\/jats:styled-content>), Gross Motor Function Measure\u201088 (<jats:styled-content style=\"fixed-case\">GMFM<\/jats:styled-content>\u201088), Manual Ability Classification System (<jats:styled-content style=\"fixed-case\">MACS<\/jats:styled-content>), and Revised Melbourne Assessment (<jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>2) scales manifested predominantly mild impairments; motor speech, moderate to severe; Modified Dysphagia Outcome and Severity Scale (M\u2010DOSS), mild\u2010to moderate deficits. GMFCS correlated with GMFM\u201088 scores (Pearson's correlation, <jats:italic>p<\/jats:italic>=0.002), MACS (<jats:italic>p<\/jats:italic>=0.038), and MA2 fluency (<jats:italic>p<\/jats:italic>=0.005) and accuracy (<jats:italic>p<\/jats:italic>=0.038) scores. GMFCS did not correlate with motor speech (<jats:italic>p<\/jats:italic>=0.399), MA2 dexterity (<jats:italic>p<\/jats:italic>=0.247), range of motion (<jats:italic>p<\/jats:italic>=0.063), or M\u2010DOSS (<jats:italic>p<\/jats:italic>=0.856). Motor speech was more severely impaired than the GMFCS (<jats:italic>p<\/jats:italic>&lt;0.013). There was no correlation between any of the assessment tools and age (<jats:italic>p<\/jats:italic>=0.210\u20100.798).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our data establish a detailed profile of motor function in alternating hemiplegia of childhood, argue against the presence of worse motor function in older patients, identify tools helpful in evaluating this population, and identify oropharyngeal function as the more severely affected domain, suggesting that brain areas controlling this function are more affected than others.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13443","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T17:12:15Z","timestamp":1495732335000},"page":"822-828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Motor function domains in alternating hemiplegia of childhood"],"prefix":"10.1111","volume":"59","author":[{"given":"Melanie","family":"Masoud","sequence":"first","affiliation":[{"name":"Duke University Health System Duke University School of Medicine Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Speech Pathology and Audiology Duke University Health System Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Physical and Occupational Therapy Duke University Health System Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Jasien","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Duke University Health System Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara","family":"Lardinois","sequence":"additional","affiliation":[{"name":"Department of Physical and Occupational Therapy Duke University Health System Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4568-5421","authenticated-orcid":false,"given":"Julie","family":"Uchitel","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Duke University Health System Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Mclean","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Duke University Health System Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyndsey","family":"Prange","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Duke University Health System Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Wuchich","sequence":"additional","affiliation":[{"name":"Cure AHC, Inc. Rolesville NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad A","family":"Mikati","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Duke University Health System Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(06)80003-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(00)00157-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2358"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000102"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0335-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq295"},{"issue":"2","key":"e_1_2_7_8_1","first-page":"S132","article-title":"Intellectual disability: definition, etiological factors, classification, diagnosis, treatment and prognosis [Discapacidad intelectual: definici\u00f3n, factores etiol\u00f3gicos, clasificaci\u00f3n, diagn\u00f3stico, tratamiento y prognosis]","volume":"50","author":"Katz G","year":"2008","journal-title":"Salud P\u00fablica M\u00e9xico"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S001216220500112X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2008.03089.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8949"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03618.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2016.02.006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/02699052.2016.1201594"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1989.tb04003.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2258"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2016.07.014"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2006.tb01313.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12965"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12391"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/17549507.2011.492874"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00009595"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-012-0298-1"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2012.04312.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2015.08.001"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22524"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdmcn.13443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.13443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T10:42:56Z","timestamp":1695984176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dmcn.13443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,25]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/dmcn.13443"],"URL":"https:\/\/doi.org\/10.1111\/dmcn.13443","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,25]]},"assertion":[{"value":"2017-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}