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Otherwise, current treatment options for neonatal brain injury mainly focus on controlling (associated) symptoms. Regeneration of the injured neonatal brain with stem cell\u2010based therapies is emerging and experimental results are promising. At present, increasing efforts are made to bring stem cell\u2010based therapies to the clinic. Among all progenitor cell types, mesenchymal stromal (stem) cells seem to be most promising for human use given their neuroregenerative properties and favourable safety profile. This review summarizes the actual state, potential hurdles and possibilities of stem cell\u2010based therapy for neonatal brain injury in the clinical setting. 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