{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:26:09Z","timestamp":1791822369326,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T00:00:00Z","timestamp":1507507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2017,12]]},"abstract":"\n Aim<\/jats:title>\n \n This study aimed to estimate long\u2010term impairment attributable to congenital cytomegalovirus infection (\n cCMV<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n This nationwide cohort study retrospectively assessed\n cCMV<\/jats:styled-content>\n in children born in 2008 in the Netherlands, testing 31\u00a0484 stored neonatal dried blood spots. Extensive medical data of\n cCMV<\/jats:styled-content>\n \u2010positive children (\n n<\/jats:italic>\n =133) and matched\n cCMV<\/jats:styled-content>\n \u2010negative comparison children (\n n<\/jats:italic>\n =274) up to 6\u00a0years of age were analysed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Moderate to severe long\u2010term impairment was diagnosed in 24.8% (33 out of 133) of all\n cCMV<\/jats:styled-content>\n \u2010positive children (53.8% in symptomatic, 17.8% in asymptomatic), compared with 12.0% (33 out of 274) of\n cCMV<\/jats:styled-content>\n \u2010negative children. Sensorineural hearing loss was seen only in five\n cCMV<\/jats:styled-content>\n \u2010positive children (3.8%). Developmental delays were diagnosed more often in\n cCMV<\/jats:styled-content>\n \u2010positive children than\n cCMV<\/jats:styled-content>\n \u2010negative children: motor (12.0% vs 1.5%), cognitive (6.0% vs 1.1%), and speech\u2013language (16.5% vs 7.3%). Long\u2010term impairment in multiple domains was more frequent in symptomatic (19.2%) and asymptomatic (8.4%)\n cCMV<\/jats:styled-content>\n \u2010positive children than\n cCMV<\/jats:styled-content>\n \u2010negative children (1.8%).\n <\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n \n Children with\n cCMV<\/jats:styled-content>\n were twice as likely to have long\u2010term impairment up to the age of 6\u00a0years, especially developmental delays and sensorineural hearing loss, than\n cCMV<\/jats:styled-content>\n \u2010negative comparison children, with a risk difference of 12.8%. These insights into the risk of\n cCMV<\/jats:styled-content>\n \u2010associated impairment can help optimize care and stimulate preventive measures.\n <\/jats:p>\n <\/jats:sec>\n \n What this paper adds<\/jats:title>\n \n \n \n Congenital cytomegalovirus infection (cCMV) leads to impairment in 25% of cases.<\/jats:p>\n <\/jats:list-item>\n \n Fifty per cent of children with cCMV symptoms at birth have long\u2010term impairment.<\/jats:p>\n <\/jats:list-item>\n \n The risk difference of moderate to severe long\u2010term impairment between children with and without cCMV is 13%, attributable to cCMV.<\/jats:p>\n <\/jats:list-item>\n \n cCMV leads to motor, cognitive, and speech\u2013language developmental delay in children.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dmcn.13556","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T02:12:41Z","timestamp":1507515161000},"page":"1261-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Long\u2010term impairment attributable to congenital cytomegalovirus infection: a retrospective cohort study"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1837-8936","authenticated-orcid":false,"given":"Marjolein J","family":"Korndewal","sequence":"first","affiliation":[{"name":"Center for Infectious Diseases, Epidemiology and Surveillance National Institute for Public Health and the Environment Bilthoven the Netherlands"},{"name":"Department of Medical Microbiology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne 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