{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:12:58Z","timestamp":1791357178971,"version":"4.3.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004875","name":"Norrbacka-Eugeniastiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004875","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the effect of intrathecal baclofen (<jats:styled-content style=\"fixed-case\">ITB<\/jats:styled-content>) on function and activity in dyskinetic cerebral palsy (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective cohort study of records from 25 children (15 males, 10 females; mean age 10y 11mo, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 4y 9mo). Five were classified in Gross Motor Function Classification level <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> and 20 in level V. Parents were interviewed about activities in daily life, sitting, communication, pain, sleep, and gross and fine motor function. Differences before and 1 year after <jats:styled-content style=\"fixed-case\">ITB<\/jats:styled-content> were graded as positive, no change, or negative. Assessments of dystonia (using the Barry\u2013Albright Dystonia Scale) and muscle tone (Ashworth Scale) were made. Joint range of motion (<jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content>) was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both dystonia and increased muscle tone, present in all participants before <jats:styled-content style=\"fixed-case\">ITB<\/jats:styled-content>, decreased after (<jats:italic>p<\/jats:italic>&lt;0.001). Passive <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> was restricted, with no difference after. Parents reported improvements in activities in daily life (<jats:italic>p<\/jats:italic>&lt;0.001), sitting (<jats:italic>p<\/jats:italic>&lt;0.001), communication (<jats:italic>p<\/jats:italic>&lt;0.001), and fine motor function (<jats:italic>p<\/jats:italic>=0.013), but no change in gross motor function. Before <jats:styled-content style=\"fixed-case\">ITB<\/jats:styled-content>, pain and disturbed sleep were reported. There was a reduction in pain (<jats:italic>p<\/jats:italic>=0.002) and sleep improved (<jats:italic>p<\/jats:italic>=0.004) after <jats:styled-content style=\"fixed-case\">ITB<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>After <jats:styled-content style=\"fixed-case\">ITB<\/jats:styled-content> in individuals with dyskinetic <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>, improvements were found in sitting, communication, and fine motor skills. There was a reduction in dystonia and muscle tone, and pain and sleep improved.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Intrathecal baclofen can affect specific aspects of functioning in dyskinetic cerebral palsy.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Sitting, communication, and fine motor function improved.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Dystonia and spasticity were reduced.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Pain was reduced and sleep improved.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13625","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T11:22:39Z","timestamp":1510917759000},"page":"94-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Intrathecal baclofen in 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