{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:51:33Z","timestamp":1791377493164,"version":"4.3.2"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>A genetic basis for autism spectrum disorder (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>) is now well established, and with the availability of high\u2010throughput microarray and sequencing platforms, major advances have been made in our understanding of genetic risk factors. Rare, often de novo, copy number and single nucleotide variants are both implicated, with many <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>\u2010implicated genes showing pleiotropy and variable penetrance. Additionally, common variants are also known to play a role in <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>'s genetic etiology. These new insights into the architecture of <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>'s genetic etiology offer opportunities for the identification of molecular targets for novel interventions, and provide new insight for families seeking genetic counselling.<\/jats:p><\/jats:sec><jats:sec><jats:title>What the paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>A number of rare genetic variants are implicated in autism spectrum disorder (ASD), with some showing recurrence.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Common genetic variants are also important and a number of loci are now being uncovered.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Genetic testing for individuals with ASD offers the opportunity to identify relevant genetic etiology.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13717","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T17:38:23Z","timestamp":1521999503000},"page":"445-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":144,"title":["Progress in the genetics of autism spectrum disorder"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0593-8917","authenticated-orcid":false,"given":"Marc","family":"Woodbury\u2010Smith","sequence":"first","affiliation":[{"name":"Institute of Neuroscience Newcastle University Newcastle Upon Tyne UK"},{"name":"Program in Genetics and Genome Biology The Centre for Applied Genomics The Hospital for Sick Children Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W","family":"Scherer","sequence":"additional","affiliation":[{"name":"Program in Genetics 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