{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:37:26Z","timestamp":1790055446235,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PS09\/01132"],"award-info":[{"award-number":["PS09\/01132"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PI12\/01951"],"award-info":[{"award-number":["FIS PI12\/01951"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PFIS0174 (PI15\/01082)"],"award-info":[{"award-number":["PFIS0174 (PI15\/01082)"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PS09\/01132"],"award-info":[{"award-number":["PS09\/01132"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["Project FIS PI 14\/00005"],"award-info":[{"award-number":["Project FIS PI 14\/00005"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000348","name":"Calouste Gulbenkian Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Gamma\u2010aminobutyric acid (<jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>) is a major modulator in brain maturation and its role in many different neurodevelopmental disorders has been widely reported. Although the involvement of <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> in different disorders has been related to its regulatory function as an inhibitory neurotransmitter in the mature brain, co\u2010transmitter, and signalling molecule, little is known about its role as a clinical biomarker in neuropaediatric disorders. The aim of this study is to report the cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>) free\u2010<jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> concentrations in a large cohort of patients (<jats:italic>n<\/jats:italic>=85) with different neurological disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> was measured in the <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> of neuropaediatric patients using capillary electrophoresis with laser\u2010induced fluorescence detection. Other neurotransmitters (amino acids and monoamines) were also analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> concentrations in <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> were abnormal, with a greater frequency (44%) than monoamines (20%) in neuropaediatric patients compared with our reference values. Although we included a few patients with inborn errors of metabolism, <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> levels in <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> were more frequently abnormal in metabolic disorders than in other nosological groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our work suggests further research into brain <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>ergic status in neuropaediatric disorders, which could also lead to new therapeutic strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Homeostasis of GABA seems more vulnerable than that of monoamines in the developing brain.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>The highest GABA levels are found in the primary GABA neurotransmitter disorder SSADH deficiency.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>GABA alterations are not specific for any clinical or neuroimaging presentation.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13746","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T06:15:29Z","timestamp":1522044929000},"page":"780-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Gamma\u2010aminobutyric acid levels in cerebrospinal fluid in neuropaediatric disorders"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8604-2230","authenticated-orcid":false,"given":"Elisenda","family":"Cort\u00e8s\u2010Saladelafont","sequence":"first","affiliation":[{"name":"Department of Neurology Neurometabolic Unit and Synaptic Metabolism Laboratory Hospital Sant Joan de D\u00e9u Barcelona Spain"},{"name":"Institut de Recerca Sant Joan de 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