{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:27:50Z","timestamp":1789021670827,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T00:00:00Z","timestamp":1521849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2018,10]]},"abstract":"\n Aim<\/jats:title>\n \n To assess the impact of perioperative neonatal brain injury and brain volumes on neurodevelopment throughout school\u2010age children with critical congenital heart disease (\n CHD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n Thirty\u2010four survivors of neonatal cardiac surgery (seven females, 27 males) were included. Neonatal preoperative and postoperative cerebral magnetic resonance imaging was performed and neurodevelopment was assessed at 24\u00a0months (\n SD<\/jats:styled-content>\n 0.7,\n n<\/jats:italic>\n =32, using Bayley Score of Infant and Toddler Development, Child Behavior Checklist) and 6\u00a0years (mean age 5y 11mo;\n SD<\/jats:styled-content>\n 0.3,\n n<\/jats:italic>\n =30, using Movement Assessment Battery for Children, Wechsler Preschool and Primary Scale of Intelligence, Child Behavior Checklist, Teacher Report Form). Brain injury, brain volumes, and cortical measures were related to outcome with adjustment for maternal educational level.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Two\u2010year cognitive score and 6\u2010year Full\u2010scale\n IQ<\/jats:styled-content>\n were poorer in children with neonatal white matter injury (\n n<\/jats:italic>\n =21, all\n p<\/jats:italic>\n <0.05), with higher teacher\u2010reported attention problems (\n p<\/jats:italic>\n =0.03). Five of six children with involvement of the posterior limb of the internal capsule showed motor problems (\n p<\/jats:italic>\n =0.03). Children with a below\u2010average Fulll\u2010scale\n IQ<\/jats:styled-content>\n (<85,\n n<\/jats:italic>\n =9) showed smaller volumes of basal ganglia thalami (\u22128%,\n p<\/jats:italic>\n =0.03) and brain stem (\u22127%,\n p<\/jats:italic>\n =0.03).\n <\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n \n Our findings provide evidence of unfavourable outcome in school\u2010age children with critical\n CHD<\/jats:styled-content>\n who acquire perioperative neonatal brain injury.\n <\/jats:p>\n <\/jats:sec>\n \n What this paper adds<\/jats:title>\n \n \n \n This paper extends knowledge about neonatal brain injury and long\u2010term outcome in congenital heart disease.<\/jats:p>\n <\/jats:list-item>\n \n Children with white matter injury show lower IQ and more attention problems at school age.<\/jats:p>\n <\/jats:list-item>\n \n Injury of the posterior limb of the internal capsule increases the risk of motor problems.<\/jats:p>\n <\/jats:list-item>\n \n This study provides evidence for worse outcomes in neonates acquiring brain injury around cardiac surgery.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dmcn.13747","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T03:14:25Z","timestamp":1521861265000},"page":"1052-1058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Perioperative neonatal brain injury is associated with worse school\u2010age neurodevelopment in children with critical congenital heart disease"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4221-2779","authenticated-orcid":false,"given":"Nathalie H P","family":"Claessens","sequence":"first","affiliation":[{"name":"Department of Neonatology Wilhelmina Children's Hospital Utrecht the Netherlands"},{"name":"Department of Pediatric Cardiology Wilhelmina Children's Hospital Utrecht the Netherlands"},{"name":"Department of Pediatric Intensive Care Wilhelmina Children's Hospital Utrecht the Netherlands"},{"name":"Brain Centre Rudolph Magnus University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma O","family":"Algra","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom L","family":"Ouwehand","sequence":"additional","affiliation":[{"name":"Department of Neonatology Wilhelmina Children's Hospital Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas J G","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Wilhelmina Children's Hospital Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renske","family":"Schappin","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology and Social Work University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiothoracic Surgery Wilhelmina Children's Hospital Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J C","family":"Eijsermans","sequence":"additional","affiliation":[{"name":"Department of Neonatology Wilhelmina Children's Hospital Utrecht the Netherlands"},{"name":"Child Development and Exercise Center University Medical Centre Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Neonatology Wilhelmina Children's Hospital Utrecht the Netherlands"},{"name":"Brain Centre Rudolph Magnus University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5491-9168","authenticated-orcid":false,"given":"Manon J N L","family":"Benders","sequence":"additional","affiliation":[{"name":"Department of Neonatology Wilhelmina Children's Hospital Utrecht the Netherlands"},{"name":"Brain Centre Rudolph Magnus University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CHD Lifespan Study Group Utrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2015.07.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.05.081"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.10.022"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003312"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829bfdcf"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.4450"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067393"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.145"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.865568"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013051"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00236-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-010-0700-y"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13461"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.99"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2015.11.012"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12350"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.08.084"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1066"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.07.022"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-837544"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.07.006"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.122"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt322"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2241"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3996-6"}],"container-title":["Developmental 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