{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:06:46Z","timestamp":1765040806057,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T00:00:00Z","timestamp":1526860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>Unlike adult neurofibromatosis type 2 (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>2), which presents with symptoms related to bilateral vestibular schwannomas, children with NF2 most frequently present with ocular, dermatological, and neurological symptoms. Arteriopathy, a well\u2010established feature in neurofibromatosis type 1, is not a widely recognized feature of <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>2. Here we report three children with <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>2 with cerebral arteriopathy and\/or arterial ischaemic stroke. Bevacizumab, a vascular endothethial growth factor inhibitor, is an established treatment for rapidly growing vestibular schwannomas; however, it carries a risk of both ischaemic and haemorrhagic stroke. Thus, the role of screening and risk to benefit ratio of bevacizumab in <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>2 merit further consideration.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Children with neurofibromatosis type 2 (NF2) may be at increased risk of cerebral vasculopathy and arterial ischaemic stroke.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Targeted magnetic resonance angiography should be performed in children with NF2 who are being considered for bevacizumab therapy.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13920","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T11:15:54Z","timestamp":1526901354000},"page":"1285-1288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cerebral vasculopathy in childhood neurofibromatosis type 2: cause for concern?"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3465-5120","authenticated-orcid":false,"given":"Karine","family":"Lascelles","sequence":"first","affiliation":[{"name":"Children's Neuroscience Centre Evelina London Children's Hospital London UK"},{"name":"Department of Neurology National Neurofibromatosis Service Guys and St Thomas NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shazia","family":"Afridi","sequence":"additional","affiliation":[{"name":"Department of Neurology National Neurofibromatosis Service Guys and St Thomas NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ata","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Children's Neuroscience Centre Evelina London Children's Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Hemingway","sequence":"additional","affiliation":[{"name":"Department of Neurology Great Ormond Street Children's Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalie","family":"Ferner","sequence":"additional","affiliation":[{"name":"Department of Neurology National Neurofibromatosis Service Guys and St Thomas NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijeya","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Department of Neurology Great Ormond Street Children's Hospital London UK"},{"name":"UCL Great Ormond Street Institute of Child Health London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52902-2.00054-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31825e73f5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nop\/npv065"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102484"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2011.00609.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedex.2013.12.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2008.02.007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34035"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162206000119"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12945"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38221"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000167134.04302.17"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199510020-00028"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.111600"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.280.6.C1375"}],"container-title":["Developmental Medicine &amp; 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