{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:52:28Z","timestamp":1781081548630,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To elucidate the natural course of benign paroxysmal torticollis, the relationship of this disorder to migraine and other paroxysmal diseases, and to analyse candidate genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a case series of children with benign paroxysmal torticollis of infancy (<jats:styled-content style=\"fixed-case\">BPTI<\/jats:styled-content>) diagnosed from 1998 to 2005, at Astrid Lindgren Children's Hospital, Stockholm, Sweden. A neurological examination and a formalized motor assessment were performed from 2005 to 2007. At a second follow\u2010up, in 2014 to 2015, the children and their parents were interviewed and candidate genes analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the eight females and three males included in the second follow\u2010up was 13 years 9 months (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 2y 2mo). All motor assessments were normal. Five had developed migraine, abdominal migraine, and\/or cyclic vomiting. Prophylactic treatment or migraine\u2010specific medication during attacks were not needed. No paroxysmal tonic upgaze, benign paroxysmal vertigo, epilepsy, episodic ataxia, or paroxysmal dyskinesia was reported. Rare genetic variants in <jats:italic><jats:styled-content style=\"fixed-case\">CACNA<\/jats:styled-content>1A<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>1A2<\/jats:italic> were found in two children. Five had a family history of migraine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>BPTI is transient and does not lead to neurological sequelae. Most children afflicted experience either a mild migraine or no paroxysmal disorder at all in their adolescence. Genetic variants in candidate genes were few, indicating potential genetic heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>After resolution of their benign paroxysmal torticollis of infancy (BPTI), children display no gross motor delay.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Most adolescents who previously had BPTI have not developed migraine.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>No mutations in candidate genes, known to cause hemiplegic migraine, were found.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Associated symptoms are often lacking during episodes of torticollis.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.13939","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T06:04:14Z","timestamp":1530252254000},"page":"1251-1255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Benign paroxysmal torticollis of infancy does not lead to neurological sequelae"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5626-7068","authenticated-orcid":false,"given":"Annika","family":"Danielsson","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden"},{"name":"Sachs' Children and Youth Hospital Stockholm South General Hospital Stockholm 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