{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:38:52Z","timestamp":1792640332137,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL) of children born preterm (gestational age &lt;32wks) after post\u2010haemorrhagic hydrocephalus requiring shunt (<jats:styled-content style=\"fixed-case\">PHH<\/jats:styled-content>\u2010S), and to examine the impact of perinatal and neurological morbidity on their QoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Forty infants (18 females, 22 males; aged 2y 2mo\u20138y 4.5mo) born preterm with <jats:styled-content style=\"fixed-case\">PHH<\/jats:styled-content>\u2010S were matched for gestational age, birthweight, and sex with infants born preterm with normal cranial ultrasonography. Pediatric QoL Inventory parent\u2010proxy report was administered at a mean age of 5 years 8 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children with <jats:styled-content style=\"fixed-case\">PHH<\/jats:styled-content>\u2010S exhibited significantly lower mean <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL compared with controls in motor (36 [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 34.9] vs 96.2 [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 6.6]), emotional (59.8 [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 26.7] vs 80.6 [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 18.8]), social (55.6 [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 29.7] vs 89.6 [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 16.6]), and school (40.5 [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 22.9] vs 89.7 [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 15.2]) domains (<jats:italic>p<\/jats:italic>&lt;0.001). Multivariate regression incorporating neonatal risk factors revealed an independent effect of parenchymal brain involvement (<jats:italic>\u03b2<\/jats:italic>=\u22120.6, <jats:italic>p<\/jats:italic>&lt;0.01) and neonatal seizures (<jats:italic>\u03b2<\/jats:italic>=\u22120.2, <jats:italic>p<\/jats:italic>&lt;0.02) on total <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL. Low <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL of children with <jats:styled-content style=\"fixed-case\">PHH<\/jats:styled-content>\u2010S was associated with neurodevelopmental morbidities: cerebral palsy (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>), epilepsy, vision and feeding problems, low cognitive, personal\u2013social, and adaptive scores (<jats:italic>p<\/jats:italic>&lt;0.05). Multivariate analysis indicated an independent contribution from severe <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> (<jats:italic>\u03b2<\/jats:italic>=\u22120.4, <jats:italic>p<\/jats:italic>&lt;0.001) and low personal\u2013social score (<jats:italic>\u03b2<\/jats:italic>=0.5, <jats:italic>p<\/jats:italic>&lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Children born preterm after <jats:styled-content style=\"fixed-case\">PHH<\/jats:styled-content>\u2010S exhibit significantly lower <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL scores compared with preterm born peers. <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL is associated with neonatal cerebral complications and neurodevelopmental morbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Children born preterm, after post\u2010haemorrhagic hydrocephalus requiring shunt, have low health\u2010related quality of life (HRQoL).<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>A low HRQoL is associated with parenchymal brain involvement and with neurological morbidity.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Severe cerebral palsy and low personal\u2013social developmental scores have independent contributions to HRQoL.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.14012","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T11:31:58Z","timestamp":1536233518000},"page":"343-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Health\u2010related quality of life after post\u2010haemorrhagic hydrocephalus in children born 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