{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:47:14Z","timestamp":1780706834854,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T00:00:00Z","timestamp":1536278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Aetiologies of first\u2010ever convulsive seizures may be diverse, not all leading to recurrence or epilepsy diagnosis. We aimed to describe the epidemiology of first\u2010ever convulsive seizures in children, investigating risk factors for recurrence and epilepsy diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a retrospective study of children presenting with a first\u2010ever convulsive seizure to a tertiary\u2010care paediatric emergency department (<jats:styled-content style=\"fixed-case\">PED<\/jats:styled-content>) in Italy, in a 12\u2010month period (2011\u20132012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and eight children (57 males, 51 females) presented to the <jats:styled-content style=\"fixed-case\">PED<\/jats:styled-content> for a first\u2010ever convulsive seizure; 90.7% were 6\u00a0months to 6\u00a0years old (median age 1y 10mo, mean 2y 7mo, range 0mo\u201314y 4mo). Seizure duration was less than 5\u00a0minutes in 76.8%. Seizures were \u2018unprovoked\u2019 in 19.4% and \u2018provoked\u2019 in 80.6%. At 4\u2010year follow\u2010up, 37.9% of patients experienced recurrence and 13.6% received a diagnosis of epilepsy. Factors significantly associated with recurrence were the \u2018unprovoked\u2019 nature of the first seizure, multiple seizures in the first 24\u00a0hours, positive family history of febrile seizures or epilepsy, and pre\u2010existing neurological conditions\/problems. Factors significantly associated with a diagnosis of epilepsy were the \u2018unprovoked\u2019 nature of the first seizure, age older than 6\u00a0years, pre\u2010existing neurological conditions\/problems, and focal onset of first seizure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Children presenting to the <jats:styled-content style=\"fixed-case\">PED<\/jats:styled-content> with first\u2010ever convulsive seizures represent a heterogeneous group. The identification of prognostic factors for recurrence and epilepsy diagnosis may help provide tailored counselling and follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Seizures were \u2018unprovoked\u2019 in 19.4% and \u2018provoked\u2019 in 80.6% of children presenting to the emergency department.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>At 4\u2010year follow\u2010up, 37.9% relapsed, and 13.6% received a diagnosis of epilepsy.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>\u2018Unprovoked\u2019 first seizure, family history of febrile seizures, and pre\u2010existing neurological conditions were associated with recurrence.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>\u2018Unprovoked\u2019 first seizure, age younger than 6\u00a0years, and pre\u2010existing neurological conditions were associated with epilepsy diagnosis.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.14015","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T10:20:25Z","timestamp":1536315625000},"page":"82-90","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["First\u2010ever convulsive seizures in children presenting to the emergency department: risk factors for seizure recurrence and diagnosis of epilepsy"],"prefix":"10.1111","volume":"61","author":[{"given":"Stefano","family":"Sartori","sequence":"first","affiliation":[{"name":"Paediatric Neurology and Neurophysiology Unit Department of Women's and Children's Health University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6395-7614","authenticated-orcid":false,"given":"Margherita","family":"Nosadini","sequence":"additional","affiliation":[{"name":"Paediatric 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