{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:06:59Z","timestamp":1791389219922,"version":"4.3.3"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002337","name":"Petre Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000924","name":"Multiple Sclerosis Research Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000942","name":"Brain Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000942","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>Myelin oligodendrocyte glycoprotein (MOG) antibodies have a strong association with acute disseminated encephalomyelitis (ADEM) in children, and bilateral and recurrent optic neuritis in children and adults. Recent reports suggest that seizures and encephalopathy may occur in children and adults with MOG antibody\u2010associated disease. We describe the clinical, laboratory, and radiological course of four MOG antibody\u2010positive children who first presented with isolated seizures without fulfilling clinical or radiological criteria for ADEM or other central nervous system demyelination syndromes, who months to years later developed more typical demyelination. This case series highlights a novel observation that isolated seizures in the absence of ADEM may be the index presentation for MOG antibody\u2010associated disease, which should therefore be considered a form of autoimmune epilepsy. It would be reasonable to test for MOG antibodies in children with seizures accompanied by subtle inflammatory changes on magnetic resonance imaging or cerebrospinal fluid analyses, particularly if followed by demyelination, given the clinical and therapeutic implications of an expedited diagnosis in minimizing long\u2010term disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Isolated seizures in the absence of acute disseminated encephalomyelitis may be the index presentation for myelin oligodendrocyte glycoprotein antibody\u2010associated demyelination.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.14032","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T12:03:44Z","timestamp":1537185824000},"page":"610-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Isolated seizures during the first episode of relapsing myelin oligodendrocyte glycoprotein antibody\u2010associated demyelination in children"],"prefix":"10.1111","volume":"61","author":[{"given":"Sudarshini","family":"Ramanathan","sequence":"first","affiliation":[{"name":"Brain Autoimmunity Group Kids Neuroscience Centre at the Children's Hospital at Westmead Sydney Medical School University of Sydney Sydney NSW Australia"},{"name":"Department of Neurology Westmead Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina L","family":"O'grady","sequence":"additional","affiliation":[{"name":"Paediatric Neuroservices Starship Children's Health Auckland District Health Board Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Malone","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Lady Cilento Children's Hospital South Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire G","family":"Spooner","sequence":"additional","affiliation":[{"name":"Paediatric Neuroservices Starship Children's Health Auckland District Health Board Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Brown","sequence":"additional","affiliation":[{"name":"New South Wales Health Pathology ICPMR Westmead NSW Australia"},{"name":"Westmead Institute for Medical Research University of Sydney Sydney NSW 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