{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:04:21Z","timestamp":1790438661553,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T00:00:00Z","timestamp":1538870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Cerebral palsy (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) remains the most significant neurological disorder associated with preterm birth. It disrupts quality of life and places huge cost burdens on society. Antenatal magnesium sulphate administration to females before 32 weeks\u2019 gestation has proven to be an effective intervention to reduce the rate of<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. In models of hypoxia, hypoxia\u2010ischemia, inflammation, and excitotoxicity in various animal species, magnesium sulphate preconditioning decreased the resulting lesion sizes and inflammatory cytokine levels, prevented cell death, and improved long\u2010term cognitive and motor behaviours. In humans, meta\u2010analyses of five randomized controlled trials using magnesium sulphate as a neuroprotectant showed prevention of<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>at 2 years. The benefit remained consistent regardless of gestational age, cause of preterm birth, and total dose received. Antenatal magnesium sulphate treatment is now recommended by the World Health Organization and by many obstetric societies. Its cost\u2010effectiveness further justifies its widespread implementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p><jats:list list-type=\"bullet\"><jats:list-item><jats:p>Neuroprotective effect of magnesium sulphate to reduce cerebral palsy in infants born preterm when administered to females at risk of imminent preterm birth.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Neuroprotection regardless of gestational age, cause of preterm birth, and total dose.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Antenatal magnesium sulphate treatment has good cost\u2010effectiveness.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.14038","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T06:25:39Z","timestamp":1538979939000},"page":"25-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Protection of brain development by antenatal magnesium sulphate for infants born preterm"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0731-5692","authenticated-orcid":false,"given":"Cl\u00e9ment","family":"Chollat","sequence":"first","affiliation":[{"name":"INSERM U1245, Genetics and Pathophysiology of Neurodevelopmental Disorders Team 4 Neovasc Institute of Research and Innovation in Biomedicine Rouen School of Medicine Normandy University Rouen France"},{"name":"Department of Neonatal Intensive Care Port Royal University Hospital APHP Paris 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