{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:30:13Z","timestamp":1779384613994,"version":"3.53.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>There are hundreds of compounds found in the marijuana plant, each contributing differently to the antiepileptic and psychiatric effects. Cannabidiol (<jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>) has the most evidence of antiepileptic efficacy and does not have the psychoactive effects of \u2206<jats:sup>9<\/jats:sup>\u2010tetrahydrocannabinol. <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> does not act via cannabinoid receptors and its antiepileptic mechanism of action is unknown. Despite considerable community interest in the use of <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> for paediatric epilepsy, there has been little evidence for its use apart from anecdotal reports, until the last year. Three randomized, placebo\u2010controlled, double\u2010blind trials in Dravet syndrome and Lennox\u2013Gastaut syndrome found that <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> produced a 38% to 41% median reduction in all seizures compared to 13% to 19% on placebo. Similarly, <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> resulted in a 39% to 46% responder rate (50% convulsive or drop\u2010seizure reduction) compared to 14% to 27% on placebo. <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> was well tolerated; however, sedation, diarrhoea, and decreased appetite were frequent. <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> shows similar efficacy to established antiepileptic drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Cannabidiol (CBD) shows similar efficacy in the severe paediatric epilepsies to other antiepileptic drugs.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Careful down\u2010titration of benzodiazepines is essential to minimize sedation with adjunctive CBD.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.14087","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T05:01:27Z","timestamp":1541566887000},"page":"13-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Efficacy of cannabinoids in paediatric epilepsy"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9177-4938","authenticated-orcid":false,"given":"Shayma","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Child Health University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2311-2174","authenticated-orcid":false,"given":"Ingrid E","family":"Scheffer","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Paediatrics University of Melbourne Melbourne Victoria Australia"},{"name":"Austin Health and Royal Children's Hospital Heidelberg Victoria Australia"},{"name":"Florey and Murdoch Children's Research Institutes Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5355-7115","authenticated-orcid":false,"given":"Lynette G","family":"Sadleir","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12631"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.6358"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1280"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14087"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13709"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01072.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12652"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.09.040"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12610"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.02.043"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1727"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342040-00003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.159145"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2013.03.009"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1711351114"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02207.x"},{"key":"e_1_2_9_18_1","volume-title":"Cannabis in the Management and Treatment of Seizures and Epilepsy: A Scientific Review","author":"Whalley B","year":"2014"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.11.009"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2016.01.004"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00379-8"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611618"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714631"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30136-3"},{"key":"e_1_2_9_25_1","unstructured":"MessenheimerJ O'BrienT BerkovicS FrenchJ Bonn\u2010MillerMO GuttermanD.Transdermal cannabidiol (CBD) gel for the treatment of focal epilepsy in adults. 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