{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:55:31Z","timestamp":1772240131434,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate fatigue, depression, and quality of life (QoL) of children with multiple sclerosis and compare to other acute demyelinating syndromes (<jats:styled-content style=\"fixed-case\">ADS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Children followed in the National Referral Centre of rare inflammatory brain and spinal diseases were included in this study. The Expanded Disability Status Scale, the fatigue severity scale, the Multiscore Depression Inventory for Children, and the Pediatric Quality of Life Inventory were used for evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven children (23 females, 14 males) were included in this study. Multiple sclerosis was diagnosed in 26 children and <jats:styled-content style=\"fixed-case\">ADS<\/jats:styled-content> in 11 children. Although not significant, severe fatigue was less frequently reported by patients with multiple sclerosis than children with <jats:styled-content style=\"fixed-case\">ADS<\/jats:styled-content> (44% vs 63%, <jats:italic>p<\/jats:italic>=0.2). Depression was reported more often in the multiple sclerosis group compared to the <jats:styled-content style=\"fixed-case\">ADS<\/jats:styled-content> group (24% vs 18%, <jats:italic>p<\/jats:italic>=0.6). Concerning the QoL in patients with multiple sclerosis, both parents and children reported poor emotional and school functioning. Physical and social functioning were rated as being good in both groups, and was significantly higher in the children's group (<jats:italic>p<\/jats:italic>=0.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>This study highlights the importance of fatigue and depression in children with <jats:styled-content style=\"fixed-case\">ADS<\/jats:styled-content> and particularly in paediatric onset multiple sclerosis. Moreover, difficulties in school and emotional functioning were the main concerns for parents and children in the multiple sclerosis group which need to be taken in account during their care and treatment proposal.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Invisible signs such as fatigue and depression affect all forms of acute demyelinating syndromes (ADS) in children.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Depression seems to be higher in children with multiple sclerosis than with other forms of ADS.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Fatigue seems to be lower in children with multiple sclerosis than with other forms of ADS.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Children with multiple sclerosis and their parents are most concerned with emotional and academic functioning.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.14242","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T10:43:48Z","timestamp":1555065828000},"page":"241-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Fatigue, depression, and quality of life in children with multiple sclerosis: a comparative study with other demyelinating diseases"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2312-6960","authenticated-orcid":false,"given":"Anca","family":"Florea","sequence":"first","affiliation":[{"name":"Pediatric Neurology Department National Referral Center for Rare Inflammatory Brain and Spinal Diseases Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Bic\u00eatre H\u00f4pitaux Universitaires Paris\u2010Sud Le Kremlin Bic\u00eatre 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