{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:46:55Z","timestamp":1790804815343,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T00:00:00Z","timestamp":1555113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dutch Duchenne Parent Project, NL"},{"name":"Children's Health Research Institute's Quality of Life Graduate Research Fellowship"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe fatigue in Duchenne muscular dystrophy (<jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>) from patients\u2019 and parents\u2019 perspectives and to explore risk factors for fatigue in children and adolescents with<jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A multicentre, cross\u2010sectional study design was used. Seventy\u2010one patients (all males; median age 12y, age range 5\u201317y) identified via the Canadian Neuromuscular Disease Registry, and their parents completed questionnaires. Subjective fatigue was assessed using the Pediatric Quality of Life Inventory Multidimensional Fatigue Scale by child self\u2010report and parent proxy\u2010report.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with<jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>across ages and disease stages experienced greater fatigue compared to typically developing controls from published data. Sleep disturbance symptoms were associated with greater fatigue by child self\u2010report (<jats:italic>\u03c1<\/jats:italic>=\u20130.42;<jats:italic>p<\/jats:italic>=0.003) and parent proxy\u2010report (<jats:italic>\u03c1<\/jats:italic>=\u20130.51;<jats:italic>p<\/jats:italic>&lt;0.001). Depressive symptoms were associated with greater fatigue by child self\u2010report (<jats:italic>\u03c1<\/jats:italic>=\u20130.46;<jats:italic>p<\/jats:italic>&lt;0.001) and parent proxy\u2010report (<jats:italic>\u03c1<\/jats:italic>=\u20130.45;<jats:italic>p<\/jats:italic>&lt;0.001). Lower functional ability was associated with greater fatigue by parent proxy\u2010report (<jats:italic>\u03c1<\/jats:italic>=0.26;<jats:italic>p<\/jats:italic>=0.03). Physical activity level, and musculoskeletal, respiratory, and cardiac function were not associated with fatigue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>In paediatric<jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>, sleep disturbance symptoms and depressive symptoms are potentially modifiable factors associated with fatigue, warranting additional investigation to facilitate the development of therapeutic strategies to reduce fatigue.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p><jats:list list-type=\"bullet\"><jats:list-item><jats:p>Fatigue is a major issue in paediatric Duchenne muscular dystrophy (DMD) across ages and disease stages.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Sleep disturbance and depressive symptoms are significantly associated with fatigue in paediatric DMD.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.14248","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T09:19:58Z","timestamp":1555147198000},"page":"245-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Fatigue in young people with Duchenne muscular dystrophy"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2134-4083","authenticated-orcid":false,"given":"Basmah","family":"El\u2010Aloul","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics Schulich School of Medicine and Dentistry Western University London ON Canada"},{"name":"Children's Health Research Institute Lawson Health Research Institute London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy 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