{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:14:48Z","timestamp":1785330888258,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To explore cortical activation during bimanual tasks and functional correlates in unilateral cerebral palsy (CP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This cross\u2010sectional study included eight participants with unilateral CP (six females, two males; mean age [SD] 20y 10mo [5y\u00a010mo], 13y 8mo\u201331y 6mo) in Manual Ability Classification System levels II to III and nine age\u2010matched participants with typical development (seven females, two males; mean age [SD] 17y 8mo [5y 7mo], 9y 4mo\u201324y 2mo). They performed bimanual symmetric squeezing (BSS) and bimanual asymmetric squeezing (BAS) tasks at 1Hz, and a pouring task with dominant hand (DPour) and a pouring task with non\u2010dominant hand (NDPour) at 0.67Hz, all while a custom array of functional near\u2010infrared spectroscopy (fNIRS) optodes were placed over their sensorimotor area. Mixed\u2010effects were used to contrast groups, tasks, and hemispheres (corrected <jats:italic>p<\/jats:italic>\u2010values [<jats:italic>q<\/jats:italic>] reported). Analysis of variance and <jats:italic>t<\/jats:italic>\u2010tests compared performance measures across groups and tasks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants with unilateral CP showed greater activation in both hemispheres during BAS (non\u2010lesioned: <jats:italic>q<\/jats:italic>&lt;0.001; lesioned: <jats:italic>q<\/jats:italic>&lt;0.001), and in the lesioned hemisphere during BSS (<jats:italic>q<\/jats:italic>&lt;0.001), DPour (<jats:italic>q<\/jats:italic>=0.02), and NDPour (<jats:italic>q<\/jats:italic>=0.02) than those with typical development. The lesioned hemisphere in unilateral CP showed more activity than the non\u2010lesioned one (BSS: <jats:italic>q<\/jats:italic>=0.01; BAS: <jats:italic>q<\/jats:italic>=0.009; NDPour: <jats:italic>q<\/jats:italic>=0.04). During BAS, higher cortical activity correlated with more synchronous arm activation (<jats:italic>r<\/jats:italic>=0.79; <jats:italic>p<\/jats:italic>=0.02); activity lateralized towards the non\u2010lesioned hemisphere correlated with better Pediatric Evaluation of Disability Inventory computer adaptive test scores (<jats:italic>r<\/jats:italic>=0.81; <jats:italic>p<\/jats:italic>=0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Results suggest abnormally increased sensorimotor cortical activity in unilateral CP, with implications to be investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Cortical activity in manual tasks is described with functional near\u2010infrared spectroscopy in typical and atypical cohorts.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Activation levels in unilateral cerebral palsy appear to escalate with task difficulty.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Increased brain activity may be associated with poorer selective manual control.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Specific patterns of brain activity may be related to impaired bimanual function.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.14458","type":"journal-article","created":{"date-parts":[[2020,2,8]],"date-time":"2020-02-08T07:11:01Z","timestamp":1581145861000},"page":"625-632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Brain activation patterns underlying upper limb bilateral motor coordination in unilateral cerebral palsy: an fNIRS study"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7267-4467","authenticated-orcid":false,"given":"Ana Carolina","family":"de Campos","sequence":"first","affiliation":[{"name":"Rehabilitation Medicine 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