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Data on study participants, design, and outcomes were extracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010two articles were included in the final review. Evidence consistently demonstrated that females with RTT can improve their gross motor, fine motor, and communicative skills with rehabilitation. All 11 interventions targeting gross motor function, namely ambulation, achieved functional improvements. Twenty of 24 articles describing fine motor rehabilitation studies succeeded in decreasing stereotypies, improving functional hand use, and\/or reducing self\u2010injurious behaviors. Twenty\u2010one of 22 studies describing communication interventions succeeded in training choice\u2010making, communicative language, or socialization behavior. Other key findings include the positive interplay between physical and communicative rehabilitation outcomes, and the ability of females with RTT to improve their cognitive abilities during intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Rehabilitation can impact the daily lives of females with RTT and their caregivers in clinically meaningful ways.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Females with Rett syndrome (RTT) can make developmental gains across their life span.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Long\u2010term intervention can improve the physical abilities of individuals with RTT.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Low\u2010, medium\u2010, and high\u2010technology interventions can improve the communicative abilities of individuals with 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