{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:54:51Z","timestamp":1784274891821,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Lauren Mantz Fund for OMS Research"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine predictors of full\u2010scale IQ (FSIQ) in an international pediatric opsoclonus myoclonus syndrome (OMS) cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this retrospective and prospective cohort study at three academic medical centers (2006\u20132013), the primary outcome measure, FSIQ, was categorized based on z\u2010score: above average (\u2265+1), average (+1 to \u20131), mildly impaired (\u20131 to \u20132), and impaired (&lt;\u20132). Univariate analysis and multivariable linear regression modeling using stepwise selection with Akaike\u2019s information criterion was performed to understand the relationship between exposures and FSIQ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 81 participants, 37 with sufficient data had mean FSIQ 84.38 (SD 20.55) and median 90 (40\u2013114) at latest available evaluation (mean age 8y 5mo). Twenty (54%), nine (24.3%), and eight (21.6%) had normal, mildly impaired, and impaired FSIQ respectively. The final multivariable linear regression model included 34 participants with evaluable data: number of relapses occurring before neuropsychological testing (<jats:italic>p<\/jats:italic>&lt;0.001) and OMS severity score at last follow\u2010up (<jats:italic>p<\/jats:italic>&lt;0.001) predicted FSIQ (adjusted <jats:italic>R<jats:sup>2<\/jats:sup><\/jats:italic>=0.64). There was a mean decrease of 2.4 FSIQ points per OMS relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Number of relapses negatively correlates with FSIQ in pediatric OMS. Demographic and clinical measures available at OMS onset did not predict FSIQ. Strategies to reduce OMS relapses may improve intellectual outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.14628","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T13:03:25Z","timestamp":1595423005000},"page":"1444-1449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["IQ predictors in pediatric opsoclonus myoclonus syndrome: a large international cohort study"],"prefix":"10.1111","volume":"62","author":[{"given":"Andrew","family":"Sheridan","sequence":"first","affiliation":[{"name":"School of Psychological Science The University of Western Australia Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kush","family":"Kapur","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children\u2019s Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferne","family":"Pinard","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children\u2019s Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Dietrich Alber","sequence":"additional","affiliation":[{"name":"Department of Neurology\/Neuropsychology University Children\u2019s Hospital Z\u00fcrich University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Camposano","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children\u2019s Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike G","family":"Pike","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Klein","sequence":"additional","affiliation":[{"name":"Division of Child Neurology University Children\u2019s Hospital Bern Inselspital University of Bern Bern Switzerland"},{"name":"Department of Pediatric Neurology University Children\u2019s Hospital Basel Basel Switzerland"},{"name":"Department of Pediatric Neurology University Children\u2019s Hospital Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3694-8832","authenticated-orcid":false,"given":"Mark P","family":"Gorman","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children\u2019s Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.01.051"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2008.04.012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2009.03.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2014.10.010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3114"},{"key":"e_1_2_8_7_1","first-page":"119","article-title":"Myoclonic encephalopathy of infants or \u2018dancing eyes syndrome\u2019. 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