{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:05:57Z","timestamp":1790834757796,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T00:00:00Z","timestamp":1604102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate outcomes after major surgery in children and adolescents with intellectual disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We used 2004 to 2013 claims data from Taiwan's National Health Insurance programme to conduct a nested cohort study, which included 220\u00a0292 surgical patients aged 6 to 17\u00a0years. A propensity score matching procedure was used to select 2173 children with intellectual disability and 21\u00a0730 children without intellectual disability for comparison. Logistic regression was used to calculate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of the postoperative complications and 30\u2010day mortality associated with intellectual disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children with intellectual disability had a higher risk of postoperative pneumonia (OR 2.16, 95% CI 1.48\u20133.15; <jats:italic>p<\/jats:italic>&lt;0.001), sepsis (OR 1.67, 95% CI 1.28\u20132.18; <jats:italic>p<\/jats:italic>&lt;0.001), and 30\u2010day mortality (OR 2.04, 95% CI 1.05\u20133.93; <jats:italic>p<\/jats:italic>=0.013) compared with children without intellectual disability. Children with intellectual disability also had longer lengths of hospital stay (<jats:italic>p<\/jats:italic>&lt;0.001) and higher medical expenditure (<jats:italic>p<\/jats:italic>&lt;0.001) when compared with children with no intellectual disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Children with intellectual disability experienced more complications and higher 30\u2010day mortality after surgery when compared with children without intellectual disability. There is an urgent need to revise the protocols for the perioperative care of this specific population.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Surgical patients with intellectual disability are at increased risk of postoperative pneumonia, sepsis, and 30\u2010day mortality.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Intellectual disability is associated with higher medical expenditure and increased length of stay in hospital after surgical procedures.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>The influence of intellectual disability on postoperative outcomes is consistent in both sexes and those aged 10 to 17 years.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Low income and a history of fractures significantly impacts postoperative adverse events for patients with intellectual disability.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.14715","type":"journal-article","created":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T04:25:06Z","timestamp":1604204706000},"page":"211-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Adverse outcomes after major surgery in children with intellectual disability"],"prefix":"10.1111","volume":"63","author":[{"given":"Shih\u2010Yu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Shuang Ho Hospital, Taipei Medical University New Taipei City Taiwan"},{"name":"Department of Anesthesiology, School of Medicine, College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuen\u2010Chau","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, School of Medicine, 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