{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:15:54Z","timestamp":1792034154432,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the efficacy of intermittent serial casting in conjunction with occupational therapy and botulinum neurotoxin A (BoNT\u2010A) in children with cerebral palsy (CP) presenting spastic wrist flexion deformity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a controlled, prospective study in which 34 children (19 females, 15 males; mean [SD] 11y [4y 6mo]) were randomly allocated to casting or control groups in a ratio of 2:1. Both groups were subjected to BoNT\u2010A treatment and occupational therapy. The casting group additionally received a series of progressive casts intermittently for three consecutive weekends. Outcome measures consisted of passive range of motion (PROM) as assessed by goniometer, muscle tone by Modified Ashworth scale (MAS), and spasticity by Tardieu Scale. Assessments were done at baseline, week 4, and week 12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline characteristics of casting and control groups were comparable. PROM, MAS, and Tardieu angle of catch (XV3) of the casting and control groups significantly improved after treatment (<jats:italic>p<\/jats:italic>&lt;0.001 for all). Nevertheless the mean change from baseline MAS at week 12, mean changes from baseline PROM, Tardieu XV3, and the spasticity grade (Y) at week 4 and week 12 of the casting group showed statistical superiority over those of the control group (<jats:italic>p<\/jats:italic>&lt;0.05 for all).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Children with CP presenting spastic wrist flexion deformity might gain additional benefits from supplementary intermittent serial casting as well as BoNT\u2010A injections and occupational therapy. Serial casting could be considered as a complementary treatment to BoNT\u2010A and occupational therapy in children with clinically significant PROM limitations.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Intermittent serial casting is a useful treatment option in children with cerebral palsy with spastic wrist flexion deformity.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Intermittent serial casting supplementation to botulinum neurotoxin A and occupational therapy provides additional benefits on passive range of motion, muscle tone, and spasticity.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.14765","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T06:43:51Z","timestamp":1611384231000},"page":"743-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Intermittent serial casting for wrist flexion deformity in children with spastic cerebral palsy: a randomized controlled trial"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6552-7204","authenticated-orcid":false,"given":"Nigar","family":"Dursun","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Physical Medicine and Rehabilitation Kocaeli University Kocaeli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugba","family":"Gokbel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Physical Medicine and Rehabilitation Kocaeli University Kocaeli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melike","family":"Akarsu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Physical Medicine and Rehabilitation Kocaeli University Kocaeli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Bonikowski","sequence":"additional","affiliation":[{"name":"Mazovian Neuropsychiatry Center Zag\u00f3rze n. Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weronika","family":"Pyrzanowska","sequence":"additional","affiliation":[{"name":"Mazovian Neuropsychiatry Center Zag\u00f3rze n. Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erbil","family":"Dursun","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Physical Medicine and Rehabilitation Kocaeli University Kocaeli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01202412-200511000-00001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215507079141"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12246"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2018.06.010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2018.08.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e31815b4d7d"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0675"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13105"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000627"},{"key":"e_1_2_8_11_1","first-page":"8","article-title":"A report: the definition and classification of cerebral palsy April 2006","volume":"109","author":"Rosenbaum P","year":"2007","journal-title":"Dev Med Child Neurol Suppl"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-9651(18)30047-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/67.2.206"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2009.11.017"},{"key":"e_1_2_8_15_1","volume-title":"Standardized assessments for the management of children with motor disorders","author":"Delgado M","year":"2020"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2010.51.4.579"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2001.00040.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073814535503"},{"key":"e_1_2_8_19_1","first-page":"CD003469","article-title":"Botulinum toxin as an adjunct to treatment in the management of the upper limb in children with spastic cerebral palsy","volume":"2010","author":"Hoare BJ","year":"2010","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.14765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dmcn.14765","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.14765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T14:45:28Z","timestamp":1692369928000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dmcn.14765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,22]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/dmcn.14765"],"URL":"https:\/\/doi.org\/10.1111\/dmcn.14765","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,22]]},"assertion":[{"value":"2020-11-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}