{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:09:33Z","timestamp":1792624173400,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008426","name":"Friedrich-Baur-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008426","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe the incidence of term and preterm neonatal cerebral sinovenous thrombosis (CSVT) and identify perinatal risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a national capture\u2010recapture calculation\u2010corrected surveillance and nested case\u2013control study. Infants born preterm and at term with magnetic resonance imaging\u2010confirmed neonatal CSVT were identified by surveillance in all paediatric hospitals in Germany (2015\u20132017). Incidence was corrected for underreporting using a capture\u2010recapture method in one federal state and then extrapolated nationwide. We reviewed PubMed for comparisons with previously reported incidence estimators. We used a population\u2010based perinatal database for quality assurance to select four controls per case and applied univariate and multivariable regression for risk factor analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010one newborn infants (34 males, 17 females; 14 born preterm) with neonatal CSVT were reported in the 3\u2010year period. The incidence of term and preterm neonatal CSVT was 6.6 (95% confidence interval [CI] 4.4\u20138.7) per 100\u00a0000 live births. Median age at time of confirmation of the diagnosis was 9.95 days (range 0\u201339d). In the univariate analysis, male sex, preterm birth, hypoxia and related indicators (umbilical artery pH &lt;7.1; 5\u2010minute Apgar score &lt;7; intubation\/mask ventilation; perinatal asphyxia), operative vaginal delivery, emergency Caesarean section, and pathological fetal Doppler sonography were associated (<jats:italic>p<\/jats:italic>&lt;0.05) with neonatal CSVT. Multivariable regression yielded hypoxia (odds ratio=20.3; 95% CI 8.1\u201350.8) as the independent risk factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Incidence of neonatal CSVT was within the range of other population\u2010based studies. The results suggest that hypoxia is an important perinatal risk factor for the aetiology of neonatal CSVT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.14816","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T07:20:53Z","timestamp":1611818453000},"page":"697-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Incidence and risk factors of cerebral sinovenous thrombosis in infants"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6255-7758","authenticated-orcid":false,"given":"Anna\u2010Lisa","family":"Sorg","sequence":"first","affiliation":[{"name":"Institute of Social Paediatrics and Adolescent Medicine Division of Paediatric Epidemiology Ludwig\u2010Maximilians\u2010University Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Von Kries","sequence":"additional","affiliation":[{"name":"Institute of Social Paediatrics and Adolescent Medicine Division of Paediatric Epidemiology Ludwig\u2010Maximilians\u2010University Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Klemme","sequence":"additional","affiliation":[{"name":"Department of Neonatology University Children\u2019s Hospital and Perinatal Centre Ludwig\u2010Maximilians\u2010University Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Gerstl","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology University Children\u2019s Hospital Ludwig\u2010Maximilians\u2010University Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Beyerlein","sequence":"additional","affiliation":[{"name":"Institute of Computational Biology Helmholtz Zentrum M\u00fcnchen Neuherberg 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