{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:35:30Z","timestamp":1780670130725,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA21765"],"award-info":[{"award-number":["CA21765"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the impact of clinical factors, cognitive deficits, and sleepiness on health\u2010related quality of life (HRQoL) among young people with craniopharyngioma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Seventy\u2010eight patients (67% White; 41 males, 37 females; mean age 10y 8mo, SD 3y 11mo, range 6\u201320y) with craniopharyngioma were assessed for tumor extent and diabetes insipidus. All patients underwent overnight polysomnography and multiple sleep latency tests after surgical resection. Executive functioning was assessed using parent\u2010reported measures. Patients and their parents completed measures of HRQoL. None had a history of previous radiation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Path analysis was used to test hypothesized relations while controlling for demographic and disease characteristics. Analyses revealed poorer parent\u2010reported HRQoL among young people with greater executive functioning symptoms (estimate \u22120.83; <jats:italic>p<\/jats:italic>&lt;0.001). Direct and indirect effects were found among diabetes insipidus, executive functioning, and parent\u2010reported HRQoL. Diabetes insipidus directly predicted greater global executive functioning impairment (estimate 5.15; <jats:italic>p<\/jats:italic>=0.04) and indirectly predicted lower HRQoL through executive functioning impairment (estimate \u22124.25; <jats:italic>p<\/jats:italic>=0.049). No significant effects were found between excessive daytime sleepiness, tumor hypothalamic involvement, diabetes insipidus, executive functioning, and patient\u2010reported HRQoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>These findings suggest that young people with craniopharyngioma presenting with diabetes insipidus may benefit from targeted neurocognitive and psychosocial screening to inform interventions.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"box\" position=\"anchor\"><jats:caption><jats:title>What this paper adds<\/jats:title><\/jats:caption><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Children with craniopharyngioma and executive functioning impairment are more likely to have poorer health\u2010related quality of life (HRQoL).<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Diabetes insipidus, a complication associated with surgery, predicted greater executive functioning impairment.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Diabetes insipidus indirectly predicted lower parent\u2010reported HRQoL through executive functioning impairment.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.14866","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T05:56:37Z","timestamp":1616478997000},"page":"984-990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Impact of sleep, neuroendocrine, and executive function on health\u2010related quality of life in young people with craniopharyngioma"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4952-4131","authenticated-orcid":false,"given":"Kristin A","family":"Niel","sequence":"first","affiliation":[{"name":"Department of Psychology St. Jude Children\u2019s Research Hospital Memphis TN 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