{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:23:37Z","timestamp":1791523417024,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the relationship between neonatal brain development and injury with early motor outcomes in infants with critical congenital heart disease (CCHD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Neonatal brain magnetic resonance imaging was performed after open\u2010heart surgery with cardiopulmonary bypass. Cortical grey matter (CGM), unmyelinated white matter, and cerebellar volumes, as well as white matter motor tract fractional anisotropy and mean diffusivity were assessed. White matter injury (WMI) and arterial ischaemic stroke (AIS) with corticospinal tract (CST) involvement were scored. Associations with motor outcomes at 3, 9, and 18\u2009months were corrected for repeated cardiac surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010one infants (31 males, 20 females) were included prospectively. Median age at neonatal surgery and postoperative brain magnetic resonance imaging was 7 days (interquartile range [IQR] 5\u201311d) and 15 days (IQR 12\u201321d) respectively. Smaller CGM and cerebellar volumes were associated with lower fine motor scores at 9 months (CGM regression coefficient=0.51, 95% confidence interval [CI]=0.15\u20130.86; cerebellum regression coefficient=3.08, 95% CI=1.07\u20135.09) and 18 months (cerebellum regression coefficient=2.08, 95% CI=0.47\u20135.12). The fractional anisotropy and mean diffusivity of white matter motor tracts were not related with motor scores. WMI was related to lower gross motor scores at 9 months (mean difference \u22120.8SD, 95% CI=\u22121.5 to \u22120.2). AIS with CST involvement increased the risk of gross motor problems and muscle tone abnormalities. Cerebral palsy (<jats:italic>n<\/jats:italic>=3) was preceded by severe ischaemic brain injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Neonatal brain development and injury are associated with fewer favourable early motor outcomes in infants with CCHD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15024","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T17:41:34Z","timestamp":1629481294000},"page":"192-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Early motor outcomes in infants with critical congenital heart disease are related to neonatal brain development and brain injury"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9874-5470","authenticated-orcid":false,"given":"Raymond","family":"Stegeman","sequence":"first","affiliation":[{"name":"Neonatology Wilhelmina Children\u2019s Hospital University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"},{"name":"Pediatric Cardiology Wilhelmina Children\u2019s Hospital University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"},{"name":"Pediatric Intensive Care Wilhelmina Children\u2019s Hospital University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"},{"name":"Congenital Cardiothoracic Surgery Wilhelmina Children\u2019s Hospital University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"},{"name":"Brain Center University Medical Center Utrecht Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike C A","family":"Sprong","sequence":"additional","affiliation":[{"name":"Center for Child Development, Exercise and Physical Literacy University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes M P J","family":"Breur","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Wilhelmina Children\u2019s Hospital University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris","family":"Groenendaal","sequence":"additional","affiliation":[{"name":"Neonatology Wilhelmina Children\u2019s Hospital University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S","family":"de Vries","sequence":"additional","affiliation":[{"name":"Neonatology Wilhelmina Children\u2019s Hospital University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Haas","sequence":"additional","affiliation":[{"name":"Congenital Cardiothoracic Surgery Wilhelmina Children\u2019s Hospital University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janjaap","family":"van der Net","sequence":"additional","affiliation":[{"name":"Center for Child Development, Exercise and Physical Literacy University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas J G","family":"Jansen","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Wilhelmina Children\u2019s Hospital University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"},{"name":"Department of Pediatrics University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon J N L","family":"Benders","sequence":"additional","affiliation":[{"name":"Neonatology Wilhelmina Children\u2019s Hospital University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"},{"name":"Brain Center University Medical Center Utrecht Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie H P","family":"Claessens","sequence":"additional","affiliation":[{"name":"Neonatology Wilhelmina Children\u2019s Hospital University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"},{"name":"Pediatric Cardiology Wilhelmina Children\u2019s Hospital University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"},{"name":"Pediatric Intensive Care Wilhelmina Children\u2019s Hospital University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"},{"name":"Congenital Cardiothoracic Surgery Wilhelmina Children\u2019s Hospital University Medical Center Utrecht, Utrecht University Utrecht the Netherlands"},{"name":"Brain Center University Medical Center Utrecht Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CHD LifeSpan Study Group Utrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2015.11.012"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101672"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13747"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6021"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47328-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.12.023"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.94"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000437298.43688.b9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13753-x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.04.022"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.01.013"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13461"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499346"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2017.1309582"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.07.017"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2016.2548501"},{"key":"e_1_2_11_18_1","unstructured":"LeemansA JeurissenB SijbersJ JonesDK.ExploreDTI: a graphical toolbox for processing analyzing and visualizing diffusion MR data. Proceedings of the 17th Annual Meeting of the International Society for Magnetic Resonance Medicine 18\u201324 April 2009; 3537; Honolulu Hawaii."},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.01.051"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.05.001"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1191\/0269215504cr730oa"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0734282906297199"},{"key":"e_1_2_11_23_1","first-page":"8","article-title":"A report: the definition and classification of cerebral palsy April 2006","volume":"109","author":"Rosenbaum P","year":"2007","journal-title":"Dev Med Child Neurol Suppl"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/026404101317108426"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.08.036"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12632"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/17518423.2015.1132280"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0633-x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.07.006"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067393"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.068"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.15024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dmcn.15024","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.15024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T13:28:10Z","timestamp":1693920490000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dmcn.15024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,20]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/dmcn.15024"],"URL":"https:\/\/doi.org\/10.1111\/dmcn.15024","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,20]]},"assertion":[{"value":"2020-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}