{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:58:28Z","timestamp":1762624708823,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:00:00Z","timestamp":1633132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe the evolution of electroencephalogram (EEG) characteristics in infants with tuberous sclerosis complex (TSC) and the relationship with neurodevelopmental outcome at 24\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Eighty\u2010three infants were enrolled in the EPISTOP trial and underwent serial EEG follow\u2010up until the age of 24\u2009months (males <jats:italic>n<\/jats:italic>=45, females <jats:italic>n<\/jats:italic>=37, median age at enrolment 28d, interquartile range 14\u201354d). Maturation of the EEG background and epileptiform discharges were compared between the <jats:italic>TSC1<\/jats:italic> and <jats:italic>TSC2<\/jats:italic> variants and between preventive and conventional groups respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children with <jats:italic>TSC2<\/jats:italic> more frequently had a slower posterior dominant rhythm (PDR) at 24 months (51% vs 11%, <jats:italic>p<\/jats:italic>=0.002), a higher number of epileptiform foci (median=8 vs 4, <jats:italic>p<\/jats:italic>=0.003), and a lower fraction of EEGs without epileptiform discharges (18% vs 61%, <jats:italic>p<\/jats:italic>=0.001) at follow\u2010up. A slower PDR at 24 months was significantly associated with lower cognitive (median=70 vs 80, <jats:italic>p<\/jats:italic>=0.028) and motor developmental quotients (median=70 vs 79, <jats:italic>p<\/jats:italic>=0.008). A higher fraction of EEGs without epileptiform discharges was associated with a lower probability of autism spectrum disorder symptoms (odds ratio=0.092, 95% confidence interval=0.009\u20130.912, <jats:italic>p<\/jats:italic>=0.042) and higher cognitive (<jats:italic>p<\/jats:italic>=0.004), language (<jats:italic>p<\/jats:italic>=0.002), and motor (<jats:italic>p<\/jats:italic>=0.001) developmental quotients at 24\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p><jats:italic>TSC2<\/jats:italic> is associated with more abnormal EEG characteristics compared to <jats:italic>TSC1<\/jats:italic>, which are predictive for neurodevelopmental outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15073","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T14:07:31Z","timestamp":1633356451000},"page":"495-501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evolution of electroencephalogram in infants with tuberous sclerosis complex and neurodevelopmental outcome: a prospective cohort study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8555-7822","authenticated-orcid":false,"given":"Jessie","family":"De Ridder","sequence":"first","affiliation":[{"name":"Department of Development and Regeneration Section\u2009Pediatric Neurology Catholic University of Leuven (KU Leuven) Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Kotulska","sequence":"additional","affiliation":[{"name":"Department of Neurology and Epileptology The Children's Memorial Health Institute Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4253-752X","authenticated-orcid":false,"given":"Paolo","family":"Curatolo","sequence":"additional","affiliation":[{"name":"Child Neurology and Psychiatry Unit Systems Medicine Department Tor Vergata University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3835-2824","authenticated-orcid":false,"given":"Anna C","family":"Jansen","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit University Hospital Brussel Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Aronica","sequence":"additional","affiliation":[{"name":"Department of (Neuro) Pathology Amsterdam University Medical Centers University of Amsterdam Amsterdam the Netherlands"},{"name":"Stichting Epilepsie Instellingen Nederland Heemstede the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Kwiatkowski","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floor E","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Child Neurology Brain Centre University Medical Centre Utrecht Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergiusz","family":"J\u00f3\u017awiak","sequence":"additional","affiliation":[{"name":"Department of Neurology and Epileptology The Children's Memorial Health Institute Warsaw Poland"},{"name":"Department of Child Neurology Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7118-0139","authenticated-orcid":false,"given":"Lieven","family":"Lagae","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration Section\u2009Pediatric Neurology Catholic University of Leuven (KU Leuven) Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Epistop Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.35"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-020-0823-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.241"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182104347"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16892"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25956"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.08.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000456659"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.204735"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.582891"},{"key":"e_1_2_10_12_1","first-page":"167","volume-title":"Niedermeyer\u2019s electroencephalography: basic principles, clinical applications, and related fields","author":"Pearl PL","year":"2017"},{"volume-title":"Current practice of clinical electroencephalography","year":"2015","author":"Ebersole JS","key":"e_1_2_10_13_1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2012.09.091"},{"volume-title":"EEG in clinical practice","year":"1994","author":"Hughes JR","key":"e_1_2_10_15_1"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091786"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8060788"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2011.03.010"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-083118-015354"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31651"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/316951"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12680"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2016.85"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22696"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.07.014"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-016-9142-0"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-014-0257-2"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.15073","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dmcn.15073","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.15073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T12:08:10Z","timestamp":1699272490000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dmcn.15073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,2]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/dmcn.15073"],"URL":"https:\/\/doi.org\/10.1111\/dmcn.15073","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"type":"print","value":"0012-1622"},{"type":"electronic","value":"1469-8749"}],"subject":[],"published":{"date-parts":[[2021,10,2]]},"assertion":[{"value":"2021-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}