{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:25:07Z","timestamp":1782210307100,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002332","name":"Semmelweis Egyetem","doi-asserted-by":"publisher","award":["EFOP\u20103.6.3\u2010VEKOP\u201016\u20102017\u201000009"],"award-info":[{"award-number":["EFOP\u20103.6.3\u2010VEKOP\u201016\u20102017\u201000009"]}],"id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the long\u2010term neurodevelopmental outcome of neonates born at term diagnosed with perinatal haemorrhagic stroke (PHS) and investigate the associations among brain territorial involvement, clinical risk factors, and neurodevelopmental outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We conducted a population\u2010based study enrolling 55 neonates born at term with PHS confirmed by magnetic resonance imaging born between 2007 and 2017. Long\u2010term neurodevelopmental outcome was assessed using the Bayley Scales of Infant Development, Second Edition, the Brunet\u2013L\u00e9zine test, and the Stanford\u2013Binet Intelligence Scales, Fifth Edition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Follow\u2010up was available in 50 (91%) of the infants, at a median age of 60\u00a0months (interquartile range 35\u201388). Forty per cent of the infants developed according to population norms, and developmental disabilities were diagnosed less frequently among neonates with frontal lobe PHS. In a multivariable model, parietal lobe PHS increased the risk for cerebral palsy (odds ratio [OR] 6.7; 95% confidence interval [CI] 1.1\u201341.4) and cognitive impairment (OR: 23.6; 95% CI: 2.9\u2013194.9), while the involvement of the thalamus and\/or basal ganglia was associated with epilepsy (OR: 7.0; 95% CI: 1.3\u201337.7). Seizures on admission were associated with epilepsy (OR: 10.8; 95% CI: 1.8\u201364.3). Patients with PHS affecting multiple lobes had poor prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Parietal lobe haemorrhage, the involvement of the thalamus\/basal ganglia, PHS affecting multiple lobes, and seizures were independent predictors of chronic neurodevelopmental sequelae, suggesting that the stroke territorial involvement and clinical risk factors influence the outcome of PHS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15149","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T09:55:54Z","timestamp":1644400554000},"page":"971-978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010term neurodevelopmental outcome of neonates born at term with perinatal haemorrhagic stroke: A population\u2010based study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1007-8875","authenticated-orcid":false,"given":"Eszter","family":"Vojcek","sequence":"first","affiliation":[{"name":"First Department of Pediatrics Semmelweis University  Budapest Hungary"},{"name":"Department of Pediatrics Szent J\u00e1nos Hospital and North Buda United Hospitals  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3zsa","family":"Gr\u00e1f","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Szent J\u00e1nos Hospital and North Buda United Hospitals  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"L\u00e1szl\u00f3","sequence":"additional","affiliation":[{"name":"Department of Applied Statistics Institute of Mathematics and Basic Sciences Hungarian University of Agriculture and Life Sciences  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyula","family":"Gyebnar","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Medical Imaging Center Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Seri","sequence":"additional","affiliation":[{"name":"First Department of Pediatrics Semmelweis University  Budapest Hungary"},{"name":"Department of Pediatrics Children\u2019s Hospital Los Angeles University of Southern California  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000247921.97794.5e"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2021.105393"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.634352"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2016.07.005"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.4151"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811413585"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01461.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2000\/421719"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.7_Spec_No.840"},{"key":"e_1_2_11_11_1","volume-title":"BSID\u2010II: Bayley Scales of infant development","author":"Bayley N","year":"1993"},{"key":"e_1_2_11_12_1","volume-title":"Brunet\u2010L\u00e9zine r\u00e9vis\u00e9: \u00e9chelle de d\u00e9veloppement psychomoteur de la premi\u00e8re enfance: manuel BLR\u2010C","author":"Brunet O","year":"1997"},{"key":"e_1_2_11_13_1","volume-title":"Stanford Binet intelligence scales","author":"Roid GH","year":"2003"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1997.tb07414.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02522.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0874"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471722146"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304068"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-4164"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.01.069"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.014186"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4163-07.2007"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2015.05.010"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn176"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.000739"}],"container-title":["Developmental Medicine &amp; 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