{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:40:56Z","timestamp":1787244056541,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2022,8]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n \n To evaluate clinical and imaging features in patients with acute necrotizing encephalopathy of childhood (ANEC) to identify predictors of\n RANBP2<\/jats:italic>\n mutations, influenza association, and long\u2010term outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n A retrospective chart review in patients with ANEC (2012\u20132020) seen at a tertiary pediatric center was performed. Children were included if they had acute inflammatory lesions in the basal ganglia and pons. Variables included presenting features, imaging characteristics,\n RANBP2<\/jats:italic>\n gene testing, nasopharyngeal swab findings, therapies, and long\u2010term outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twenty patients were included (average age at presentation 3y 6mo, interquartile range\u00a0\u00a03y 7mo, SD\u00a0\u00a02y 8mo; 14 females, six males). Three of the 20 experienced recurrences; one of the 20 died. Ten patients were influenza positive. Seven patients were\n RANBP2<\/jats:italic>\n mutation positive. A higher likelihood of hemorrhage was observed in patients who were influenza positive compared to influenza negative (\n p<\/jats:italic>\n =0.048). Patients with influenza had a higher degree of thalamic hemorrhage (2,\n p<\/jats:italic>\n =0.035) and greater extent of diffusion restriction (3,\n p<\/jats:italic>\n =0.035) in semiquantitive analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n \n Children with ANEC who are positive for influenza are more likely to have hemorrhage and greater thalamic swelling.\n RANBP2<\/jats:italic>\n status was predictive of relapse but not predictive of overall outcome.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dmcn.15165","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T12:39:45Z","timestamp":1643805585000},"page":"1008-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Outcomes in influenza and\n RANBP2<\/i>\n mutation\u2010associated acute necrotizing encephalopathy of childhood"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2091-8471","authenticated-orcid":false,"given":"Nurin","family":"Chatur","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Neurology Hospital for Sick Children Division of Neuroscience and Mental Health SickKids Research Institute Toronto Ontario Canada"},{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Yea","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Neurology Hospital for Sick Children Division of Neuroscience and Mental Health SickKids Research Institute Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Ertl\u2010Wagner","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Diagnostic Imaging Hospital for Sick Children, University of Toronto, Division of Neuroscience and Mental Health, SickKids Research Institute Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5393-7417","authenticated-orcid":false,"given":"E. Ann","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Neurology Hospital for Sick Children Division of Neuroscience and Mental Health SickKids Research Institute Toronto Ontario Canada"},{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.12.009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1984"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811417873"},{"issue":"9","key":"e_1_2_8_5_1","first-page":"1919","article-title":"Acute necrotizing encephalopathy of childhood: correlation of MR findings and clinical outcome","volume":"27","author":"Wong A","year":"2006","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.58.5.555"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/792578","article-title":"Acute necrotizing encephalopathy: an underrecognized clinicoradiologic disorder","volume":"2015","author":"Wu X","year":"2015","journal-title":"Mediators Inflamm"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(00)00199-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/spid.2002.122993"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(03)00008-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2005.07.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/651501"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2003.tb00969.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/377101"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2003.01822.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2005.08.030"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000115631.99896.41"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2008.03.005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2019.34.e143"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2016.05.002"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738060210101401"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(96)00063-0"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2014.11.010"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2016.02.007"},{"key":"e_1_2_8_25_1","unstructured":"Online Mendelian Inheritance in Man.MIM NUMBER: 601181: 2019. 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