{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:30:03Z","timestamp":1762608603407,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the clinical characteristics and prevalence of paediatric anti\u2010myelin oligodendrocyte glycoprotein (MOG) antibody\u2010associated autoimmune encephalitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 94 paediatric patients (46 males, 48 females, median age 9 years 5 months, range: 8 months\u201317 years 8 months) with autoimmune encephalitis were recruited at Seoul National University Children\u2019s Hospital. We evaluated autoantibody status and identified patients with anti\u2010MOG antibody\u2010associated autoimmune encephalitis. Retrospective reviews of medical records were performed to describe clinical presentations, laboratory findings, treatments, and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight patients (five males, three females, median age 11 years 9 months) with anti\u2010MOG antibody\u2010associated encephalitis were identified (8.5% of those with autoimmune encephalitis), one of whom was copositive for anti\u2010<jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010aspartate receptor (NMDAR) antibodies. Anti\u2010NMDAR antibodies were identified in 23 patients (23 out of 94, 24.5%). Unilateral or bilateral cortical involvement was identified in five patients. Focal contrast enhancement was also identified in three of the five patients with cortical lesions. All patients showed favourable response to immunotherapy with a Modified Rankin Scale \u22642 at the last follow\u2010up. Relapse was found in one patient and clinico\u2010radiological remission was achieved with cyclic intravenous immunoglobulin therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Anti\u2010MOG antibody\u2010associated encephalitis accounts for a significant proportion of clinically defined paediatric patients with autoimmune encephalitis. Anti\u2010MOG antibody\u2010associated encephalitis should be included in the clinical spectrum of anti\u2010MOG\u2010associated diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15174","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T08:46:34Z","timestamp":1643791594000},"page":"998-1007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinico\u2010radiological characteristics of anti\u2010myelin oligodendrocyte glycoprotein antibody\u2010associated autoimmune encephalitis in children"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8671-5215","authenticated-orcid":false,"given":"Ji Yeon","family":"Han","sequence":"first","affiliation":[{"name":"Department of Pediatrics Seoul National University Children\u2019s Hospital  Seoul Republic of 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