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Data from 15 studies (pre\u2010therapeutic hypothermia, 10; therapeutic hypothermia, five) were available for meta\u2010analysis. Pooled sensitivity and specificity, summary area under the receiver operating characteristic curve, and diagnostic odds ratio of resistive index or CBFV for predicting \u2018death or severe disability\u2019 were as follows. Pre\u2010therapeutic hypothermia era: 0.83 (95% confidence interval [CI] 0.45\u20130.97) and 0.92 (95% CI 0.74\u20130.98), 0.94 (95% CI 0.92\u20130.96), 54 (95% CI 7\u2013391). Therapeutic hypothermia era (measurements before therapeutic hypothermia): 0.62 (95% CI 0.41\u20130.80) and 0.96 (95% CI 0.88\u20130.99), 0.93 (95% CI 0.89\u20130.94), 23 (95% CI 6\u201391). Therapeutic hypothermia era (measurements during\/after therapeutic hypothermia): 0.51 (95% CI 0.24\u20130.78) and 0.83 (95% CI 0.73\u20130.90), 0.81 (95% CI 0.78\u20130.85), 5 (95% CI 2\u201313). Overall Grading of Recommendations Assessment, Development and Evaluation (GRADE) rating of evidence was \u2018low\u2019 or \u2018very low\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Low\u2010level evidence suggests that abnormal resistive index or CBFV can predict death or disability with high sensitivity and specificity in infants with HIE who are not cooled. The specificity of these tests was high when performed before starting cooling in infants who received therapeutic hypothermia.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Cerebral doppler ultrasound may be useful in predicting death or disability in infants with hypoxic\u2010ischaemic encephalopathy who are not cooled.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Cerebral doppler ultrasound may also be useful in infants who are cooled, if done before starting cooling.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Cerebral doppler ultrasound may not be useful when performed during or after completing cooling.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15236","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T18:58:01Z","timestamp":1649357881000},"page":"1202-1213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Does abnormal Doppler on cranial ultrasound predict disability in infants with hypoxic\u2010ischaemic encephalopathy? 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