{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:30:16Z","timestamp":1791639016367,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the prognostic value of conventional electroencephalography (EEG) monitoring in neonatal hypoxic\u2013ischemic encephalopathy (HIE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this multicentre retrospective study, 95 full\u2010term neonates (mean of 39.3wks gestational age [SD\u00a0\u00a01.4], 36 [38%] females, 59 [62%] males) with HIE (2013\u20132016) undergoing therapeutic hypothermia were divided between favourable or adverse outcomes. Background EEG activity (French classification scale: 0\u20131\u20132\u20103\u20104\u20105) and epileptic seizure burden (epileptic seizure scale: 0\u20131\u20102) were graded for seven 6\u2010hour periods. Conventional EEG monitoring was investigated by principal component analysis (PCA), with clustering methods to extract prognostic biomarkers of development at 2\u2009years and infant death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010one per cent of infants with an adverse outcome had a French classification scale equal to or greater than 3 after H48 (100% at H6\u201312). The H6\u201312 epileptic seizure scale was equal to or greater than 1 for 39%, increased to 52% at H30\u201336 and then remained equal to or greater than 1 for 39% after H48. Forty\u2010five per cent of infants with a favourable outcome had a H6\u201312 French classification scale equal to or greater than 3, which dropped to 5% after H48; 13% had a H6\u201312 epileptic seizure scale equal to or greater than 1 but no seizures after H48. Clustering methods based on PCA showed the high efficiency (96%) of conventional EEG monitoring for outcome prediction and allowed the definition of three prognostic EEG biomarkers: H6\u201378 French classification scale mean, H6\u201378 French classification scale slope, and H30\u201378 epileptic seizure scale mean.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Early lability and recovery of physiological features is prognostic of a favourable outcome. Seizure onset from the second day should also be considered to accurately predict neurodevelopment in HIE and support the importance of conventional EEG monitoring in HIE in infants cooled with therapeutic hypothermia.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Comprehensive analysis showed the high prognostic efficiency (96%) of conventional electroencephalography (EEG) monitoring.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Prognostic EEG biomarkers consist of the grade of background EEG activity, its evolution, and the mean seizure burden.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Persistent seizures (H48) without an improvement in background EEG activity were consistently associated with an adverse outcome.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15302","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T06:04:30Z","timestamp":1655445870000},"page":"58-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The prognostic value of neonatal conventional\u2010EEG monitoring in\u00a0hypoxic\u2010ischemic encephalopathy during therapeutic hypothermia"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7001-0250","authenticated-orcid":false,"given":"Emilie","family":"Bourel\u2010Ponchel","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche 1105, Research Group on Multimodal Analysis of Brain Function University of Picardie Jules Verne  Amiens France"},{"name":"Pediatric Neurophysiology Unit Amiens Picardie 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