{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T02:26:07Z","timestamp":1792981567638,"version":"4.5.0"},"reference-count":106,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Assisted reproductive technology (ART) includes fertility treatment in which either eggs or embryos are handled outside a female's body to promote successful pregnancies and healthy offspring. Current ART procedures encompass in vitro fertilization with or without intracytoplasmic sperm injection. The most common complication of ART is related to the consequences of multiple pregnancy, which can be prevented or minimized by reducing the number of embryos transferred to the uterus, commonly single embryo transfer. ART has been shown to be variably associated with adverse short\u2010 and long\u2010term perinatal outcomes, including cerebral palsy, autism, neurodevelopmental imprinting disorders, and cancer. However, there is uncertainty as to whether reported problems are related to the ART procedure itself, to factors related to infertility, to other medical and environmental factors, or a combination thereof. From a pathophysiological perspective, whether ART alters epigenetic mechanisms of gene expression, leading to later developmental, medical, and behavioral disorders, is an area of active investigation. With the meticulously conducted short\u2010 and long\u2010term outcome studies completed so far, overall, and after controlling for multiple gestations and preterm delivery, the results suggest that ART is a safe procedure, offering hope to many parent(s) wishing for a healthy child. This paper highlights ART methods and the risk factors and confounders in the interpretation of short\u2010 and long\u2010term outcome data, providing the reader with a means to evaluate findings and conclusions of outcome studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>What this paper adds<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Assisted reproductive technology (ART) is a relatively safe procedure.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Single embryo implantation optimizes outcome.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Informed consent, including the risks and benefits of ART, should be required.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Ongoing longitudinal studies are necessary to fully understand ART outcomes.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.15332","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T02:10:11Z","timestamp":1658196611000},"page":"38-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":197,"title":["Assisted reproductive technology: Short\u2010 and long\u2010term outcomes"],"prefix":"10.1111","volume":"65","author":[{"given":"Mary Elaine","family":"Graham","sequence":"first","affiliation":[{"name":"College of Arts and Sciences Washington and Lee University  Lexington VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angie","family":"Jelin","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine Johns Hopkins University School of Medicine  Baltimore MD USA"},{"name":"Department of Gynecology and Obstetrics, Division of Maternal\u2010Fetal Medicine Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Alexander H.","family":"Hoon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Developmental Medicine Johns Hopkins School of Medicine  Baltimore MD USA"},{"name":"Phelps Center for Cerebral Palsy and Neurodevelopmental Medicine Kennedy Krieger Institute  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8073-0131","authenticated-orcid":false,"given":"Anna Maria","family":"Wilms Floet","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Developmental Medicine Johns Hopkins School of Medicine  Baltimore MD USA"},{"name":"Center for Autism and Related Disorders Kennedy Krieger Institute  Baltimore MD USA"},{"name":"Center for Development and Learning Kennedy Krieger Institute  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Levey","sequence":"additional","affiliation":[{"name":"Health Services for Children with Special Needs  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest M.","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Maternal\u2010Fetal Medicine Johns Hopkins University School of Medicine  Baltimore MD USA"},{"name":"Neuroscience Intensive Care Nursery Program Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.03.008"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92957-4"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92425-F"},{"key":"e_1_2_17_5_1","unstructured":"NationalARTSurveillance [Internet].2021[cited 2022 Apr 18]. 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