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Early signs of ASD emerge between 6 and 12\u2009months: reduced social communication, slightly less advanced motor development, and repetitive behaviour. The fronto\u2010temporo\u2010parietal cortex and cerebellum play a prominent role in the development of social communication, whereas fronto\u2010parietal\u2010cerebellar networks are involved in the planning of movements, that is, movement selection. Atypical sensory responsivity, a core feature of ASD, may result in impaired development of social communication and motor skills and\/or selection of atypical repetitive behaviour. In the first postnatal year, the brain areas involved are characterized by gradual dissolution of temporary structures: the fronto\u2010temporo\u2010parietal cortical subplate and cerebellar external granular layer. It is hypothesized that altered dissolution of the transient structures opens the window for the expression of early signs of ASD arising in the impaired developing permanent networks.<\/jats:p><\/jats:sec><jats:sec><jats:title>What this paper adds<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>The early social and motor signs of autism spectrum disorder emerge between the ages of 6 and 12\u2009months.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Altered dissolution of transient brain structures in the fronto\u2010temporo\u2010parietal cortex and cerebellum may underlie the emergence of these early signs.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.15333","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T12:05:59Z","timestamp":1657281959000},"page":"1344-1350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Emerging signs of autism spectrum disorder in infancy: Putative neural substrate"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6845-5114","authenticated-orcid":false,"given":"Mijna","family":"Hadders\u2010Algra","sequence":"first","affiliation":[{"name":"University of Groningen, University Medical Center Groningen Department of Paediatrics, Section of Developmental Neurology  Groningen the Netherlands"},{"name":"University of Groningen, Faculty of Theology and Religious Studies  Groningen the 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