{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:07Z","timestamp":1787014087085,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T00:00:00Z","timestamp":1658620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009408","name":"Fondation Brain Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["Frederick Banting and Charles Best Canada Graduate Scholarship\u2014Doctoral Award"],"award-info":[{"award-number":["Frederick Banting and Charles Best Canada Graduate Scholarship\u2014Doctoral Award"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2023,1]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n To describe the clinical course of pain intensity in individuals with cerebral palsy (CP) resulting from usual care or specific interventions.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n We conducted an exploratory prognostic systematic review searching electronic databases from inception to 31st December 2021. Evidence from low and moderate risk\u2010of\u2010bias studies was synthesized.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We retrieved 2275 citations; 18 studies met the inclusion criteria and 10 were synthesized. The course of pain intensity in children with CP receiving usual care was stable over 15\u2009weeks (\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n [2]<\/jats:sub>\n \u00a0=\u00a01.8,\n p<\/jats:italic>\n \u00a0=\u00a00.5). Children who received continuous intrathecal baclofen (CITB) reported significant pain intensity reduction (visual analogue scale [VAS]\u00a0=\u00a0\u22124.2 out of 10, 95% confidence interval [CI]\u00a0=\u00a0\u22126.3 to \u22122.1]) 6\u2009months postinsertion but similar children receiving usual care had no significant change over 6\u2009months (VAS\u00a0=\u00a01.3 out of 10, 95% CI\u00a0=\u00a0\u22121.3 to 3.6). Children receiving botulinum neurotoxin A (BoNT\u2010A) injections had significant decreases in pain after 1\u2009month (numeric rating scale\u00a0=\u00a0\u22126.5, 95% CI\u00a0=\u00a0\u22128.0 to \u22125.0). Adults with chronic pain receiving usual care reported stable pain intensity over time; pain intensity improved in ambulatory adults exercising and those treated surgically for cervical myelopathy.\n <\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n The course of pain intensity in individuals with CP is unclear. Evidence suggests that children and adults receiving usual care had stable pain intensity over the short or long term. Interventions (CITB and BoNT\u2010A in children and exercise and surgical treatment for cervical myelopathy in adults) had pain intensity reduction. Larger study samples are needed to confirm these results.<\/jats:p>\n <\/jats:sec>\n \n What this paper adds<\/jats:title>\n \n \n \n Pain intensity was stable in children with cerebral palsy (CP) receiving usual care.<\/jats:p>\n <\/jats:list-item>\n \n Adults with CP and chronic pain receiving usual care had stable, persistent pain intensity.<\/jats:p>\n <\/jats:list-item>\n \n Children receiving continuous intrathecal baclofen via pump and botulinum neurotoxin A reported significantly lower pain intensities.<\/jats:p>\n <\/jats:list-item>\n \n Adults with chronic pain and dyskinetic CP and cervical myelopathy reported significantly lower pain intensity with exercise or cervical decompression.<\/jats:p>\n <\/jats:list-item>\n \n Limited high\u2010quality evidence exists describing non\u2010procedural pain changes in individuals with CP.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n 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